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2,4-Dichlorophenol

General Description

  • Synonyms: 2,4-DCP; DCP
  • OSHA IMIS Code Number: 0895
  • Chemical Abstracts Service (CAS) Registry Number: 120-83-2
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: SK8575000
  • Chemical Description and Physical Properties:
    • needle-like crystals with a characteristic medicinal taste and odor
    • molecular weight: 163.0
    • vapor pressure: 133 kPa @ 53°C
    • molecular formula: C6H4Cl2O
    • boiling point: 210°C
    • melting point: 45°C
    • flash point: 114°C open cup
  • Incompatibilities: reacts violently with strong oxidants

Health Factors

  • Carcinogenic Classification:
  • Potential Symptoms: Irritation of eyes, nose, throat, skin; cough, sore throat, shortness of breath; eye redness, pain, burns; skin redness, pain, blisters; Ingestion Acute: Burning sensation, abdominal pain; labored breathing; weakness, tremor, convulsions; shock or collapse; Skin Absorption.
  • Health Effects: Acute toxicity (HE4); Irritation-Eyes, Nose, Throat, Skin---Marked (HE14).
  • Affected Organs: Skin, eyes, CNS
  • Notes:
    1. OSHA does not have a PEL for 2,4-dichlorophenol (2,4-DCP).
    2. EPA's oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for 2,4-DCP is 0.003 mg/kg/day.
    3. Skin contact with liquid 2,4-DCP should be treated as a life-threatening medical emergency, as several deaths from accidental splashing or spraying at work have been reported, and there is no known antidote.
    4. The NOAEL for 2,4-DCP in rats that received it orally in their food for 10 weeks was reported to be 33-49 mg/kg/day.
    5. The measurement of urinary 2,4-DCP is not specific for one parent compound, as it can be a metabolite of the organophosphate pesticides, dichlofention and prothiofos, as well as of the organochlorine pesticides, 1,3-dichlorobenzene, bifenox, diclofop, 2,4-dichlorophenoxybutyric acid, dichloroprop, and nitrofen.
  • Literature Basis:
    • International Chemical Safety Cards (WHO/IPCS/ILO): 2,4-Dichlorophenol.
    • U.S. EPA Integrated Risk Information System: 2,4-Dichlorophenol (CASRN 120-83-2).
    • Aoyama, H., et al.: A two-generation reproductive toxicity study of 2,4-dichlorophenol in rats. J. Toxicol. Sci. 30(Special issue): 59-78, 2005.
    • Center for Disease Control and Prevention: Occupational fatalities associated with 2,4-dichlorophenol (2,4-DCP) exposure, 1980-1998. MMWR Morb. Mortal. Wkly. Rep. 49(23): 516-518, 2000.
    • Mage, D.T., Allen, R.H., Gondy, G., Smith, W., Barr, D.B. and Needham, L.L.: Estimating pesticide dose from urinary pesticide concentration data by creatinine correction in the Third National Health and Nutrition Examination Survey (NHANES-III). J. Expo. Anal. Environ. Epidemiol. 14(6): 457-465, 2004.
    • Pohanish, R.P. (editor): 2,4-Dichlorophenol. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 826-828.
  • Date Last Revised: 03/29/2007

Monitoring Methods used by OSHA

Bulk Method:
  • Limit the amount of bulk submitted to one gram or approx. one mL.

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