<< Back to Chemical Sampling Information
Synonyms: 1,3-Dichlorobenzene; m-Dichlorobenzol; m-Phenylene dichloride
OSHA IMIS Code Number: D149
Chemical Abstracts Service (CAS) Registry Number: 541-73-1
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: CZ4499000
Chemical Description and Physical Properties:
molecular weight: 147.0
vapor pressure: 0.286 kPa @ 25°C
molecular formula: C6H4Cl2
boiling point: 173°C
melting point: -24.8°C
63°C closed cup
Incompatibilities: reacts violently with aluminium
Environmental Protection Agency (EPA): Group D, not classifiable as to human carcinogenicity
International Agency for Research on Cancer (IARC): Group 3, not classifiable as to its carcinogenicity to humans [134 KB PDF, pages]
Potential Symptoms: Irritation of eyes, nose, throat, skin; cough, sore throat; drowsiness, nausea, vomiting; skin blisters; in animals: liver, kidney damage; INGES. ACUTE: Burning sensation; nausea, vomiting, diarrhea.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); Liver damage (HE4)
Affected Organs: Eyes, skin, respiratory system, liver
- OSHA does not have a PEL for m-dichlorobenzene.
- Explosive vapor/air mixtures of m-dichlorobenzene may be formed at temperatures above 63°C.
- Urinary metabolites of m-dichlorobenzene in rats include 2,4- and 3,5-dichlorophenyl methyl sulfoxides and methyl sulfones, as well as mercapturic acid derivatives.
- The hepatotoxicity of m-dichlorobenzene may be due to production of reactive metabolites that bind covalently to liver proteins, as well as to oxidative stress from the intracellular depletion of reduced glutathione (GSH). Hepatotoxicity in rats is markedly increased by pretreatment with phenobarbital to induce metabolizing enzymes.
- International Chemical Safety Cards (WHO/IPCS/ILO): 1,3-Dichlorobenzene.
- U.S. EPA Integrated Risk Information System: 1,3-Dichlorobenzene (CASRN 541-73-1).
- Kimura, R., Sano, H., Itagaki, K., Kogure, T., Sato, M. and Murata, T.: Identification of sulfer-containing metabolites of m-dichlorobenzene and their disposition and relationship with glutathione in rats. J. Pharmacobiodyn. 7(4): 234-245, 1984.
- McCauley, P.T., Robinson, M., Daniel, F.B. and Olson, G.R.: Toxicity studies of 1,3-dichlorobenzene in Sprague-Dawley rats. Drug Chem. Toxicol. 18(2-3): 201-221, 1995.
- No authors listed: Dichlorobenzenes [134 KB PDF, 54 pages]. IARC Monogr. Eval. Carcinog. Risks Hum. 73: 223-276, 1999.
- Pohanish, R.P. (editor): Dichlorobenzenes. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 799-804.
- Stine, E.R., Gunawardhana, L. and Sipes, I.G.: The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer specific and strain-specific differential toxicity. Toxicol. Appl. Pharmacol. 109(3): 472-481, 1991.
Date Last Revised: 03/28/2007
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: Carbon Disulfide
maximum volume: 10 Liters
maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA modified NIOSH Analytical Method (NIOSH 1003 [113 KB PDF, 7 pages])
method classification: Partially Validated
** All Trademarks are the property of their respective owners.
Accessibility Assistance: Contact the OSHA Directorate of Technical Support and Emergency Management at (202) 693-2300 for assistance accessing PDF materials.