Explosive vapor/air mixtures of m-dichlorobenzene may be formed at temperatures above 63°C.
Urinary metabolites of m-dichlorobenzene in rats include 2,4- and 3,5-dichlorophenyl methyl sulfoxides and methyl sulfones, as well as mercapturic acid derivatives.
The hepatotoxicity of m-dichlorobenzene may be due to production of reactive metabolites that bind covalently to liver proteins, as well as to oxidative stress from the intracellular depletion of reduced glutathione (GSH). Hepatotoxicity in rats is markedly increased by pretreatment with phenobarbital to induce metabolizing enzymes.
Kimura, R., Sano, H., Itagaki, K., Kogure, T., Sato, M. and Murata, T.: Identification of sulfer-containing metabolites of m-dichlorobenzene and their disposition and relationship with glutathione in rats. J. Pharmacobiodyn. 7(4): 234-245, 1984.
McCauley, P.T., Robinson, M., Daniel, F.B. and Olson, G.R.: Toxicity studies of 1,3-dichlorobenzene in Sprague-Dawley rats. Drug Chem. Toxicol. 18(2-3): 201-221, 1995.
Pohanish, R.P. (editor): Dichlorobenzenes. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 799-804.
Stine, E.R., Gunawardhana, L. and Sipes, I.G.: The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer specific and strain-specific differential toxicity. Toxicol. Appl. Pharmacol. 109(3): 472-481, 1991.
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