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Chemical Sampling Information (CSI)
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General Description

Synonyms: O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidinyl)- phosphorthioate; Spectracide; Phosphorothioic acid, O,O-diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) ester

OSHA IMIS Code Number: 2720

Chemical Abstracts Service (CAS) Registry Number: 333-41-5

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: TF3325000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2783 152

NIOSH Pocket Guide to Chemical Hazards, Diazinon®: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 mg/m3 TWA - Inhalable fraction and vapor; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen; BEIA: see BEI® for Acetylcholinesterase Inhibiting Pesticides

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.1 mg/m3 TWA; Skin

Health Factors

Potential Symptoms: Eye irritation, miosis, blurred vision; headache, dizziness, confusion, lassitude (weakness, exhaustion); convulsions; dyspnea (breathing difficulty); excessive salivation, sweating; abdominal cramps, nausea, vomiting, diarrhea; unconsciousness

Health Effects: Cholinesterase inhibition (HE6); Suspect teratogen (HE5); Mutagen (HE2)

Affected Organs: Eyes, respiratory system, CNS, cardiovascular system, blood cholinesterase

Notes:

  1. OSHA does not have a PEL for diazinon.
  2. Diazinon« is activated to the cholinesterase inhibitor diazoxon predominantly by cytochrome P450 2C19.
  3. Biomarkers of exposure include measurement of cholinesterase activity in blood plasma and in red blood cells and urinary dialkyl phosphate metabolites.
  4. Urinary metabolites include diethyl phosphate and diethyl thiophosphate. which have an elimination half-life in urine of approximately two hours in human volunteers following oral administration of diazinon (11 Ág/kg body weight) and an elimination half-life of about nine hours after dermal application of 100 mg.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Diazinon«.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Diazinon.
  • Garfitt, S.J., Jones, K., Mason, H.J. and Cocker, J.: Exposure to the organophosphate diazinon: data from a human volunteer study with oral and dermal doses. Toxicol. Lett. 134(1-3): 105-113, 2002.
  • Kappers, W.A., Edwards, R.J., Murray, S. and Boobis, A.R.: Diazinon« is activated by CYP2C19 in human liver. Toxicol. Appl. Pharmacol. 177(1): 68-76, 2001.
  • Pohanish, R.P. (editor): Diazinon«. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 770-772.

Date Last Revised: 07/01/2005

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: OSHA Versatile Sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg sections, 20/60 mesh) with Glass Fiber Filter enclosed
    maximum volume: 480 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: Gas Chromatography; GC/FPD
    method reference: OSHA Analytical Method (OSHA 62)
    method classification: Fully Validated
    note: OSHA personnel may obtain sampling tubes from the Salt Lake Technical Center.

Bulk Method:

  • Limit the amount of bulk submitted to one gram or one mL.

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