- Synonyms: Anone; Pimelic ketone; Cyclohexyl ketone; Ketohexamethylene
- OSHA IMIS Code Number: 0830
- Chemical Abstracts Service (CAS) Registry Number: 108-94-1
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: GW1050000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 1915 127
- NIOSH Pocket Guide to Chemical Hazards, Cyclohexanone: chemical description, physical properties, potentially hazardous incompatibilities, and more
- OSHA Permissible Exposure Limit (PEL):
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 20 ppm, 80 mg/m3 TWA; 50 ppm, 200 mg/m3 STEL; Skin; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 25 ppm, 100 mg/m3 TWA; Skin
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 700 ppm
- Potential Symptoms: Irritation of eyes, skin, mucous membrane; headache; narcosis; coma; dermatitis; in animals: liver, kidney damage
- Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); Cumulative liver and kidney damage (HE3); Narcosis (HE8)
- Affected Organs: Eyes, skin, respiratory system, CNS, liver, kidneys
- Above 44ºC, explosive vapor/air mixtures may be formed.
- EPA's oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for cyclohexanone is 5 mg/kg/day.
- Two cases of contact dermatitis due to cyclohexanone exposure have been reported.
- In a study with human volunteers who inhaled cyclohexanone for 8 hours, the major urinary metabolites over 72 hours were found to be 1,2-cyclohexanediol (38-41% of dose) and 1,4-cyclohexanediol (18-21% of dose), including their glucuronide conjugates. These metabolites appeared to be useful for biomonitoring exposure to cyclohexanone.
- NIOSH Pocket Guide to Chemical Hazards: Cyclohexanone.
- International Chemical Safety Cards (WHO/IPCS/ILO): Cyclohexanone.
- U.S. EPA Integrated Risk Information System: Cyclohexanone (CASRN 108-94-1).
- Mráz, J., Gálová, E., Nohová, H. and Vítková, D.: Uptake, metabolism and elimination of cyclohexanone in humans. Int. Arch. Occup. Environ. Health 66(3): 203-208, 1994.
- Pazzaglio, M., Tullo, S., Voudouris, S. and Tosti, A.: Contact dermatitis due to cyclohexanone: a further case. Contact Dermatitis 49(6): 313, 2003.
- Pohanish, R.P. (editor): Cyclohexanone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 719-721.
Date Last Revised: 05/05/2006
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Chromosorb 106 Tube (100/50 sections, 60/80 mesh)
- analytical solvent: Carbon Disulfide
- maximum volume: 10 Liters
- maximum flow rate: 0.2 L/min
- current analytical method: Gas Chromatography; GC/FID
- method reference: OSHA Analytical Method (OSHA 1)
- method classification: Fully Validated
** All Trademarks are the property of their respective owners.