<< Back to Chemical Sampling Information

Chemical Sampling Information (CSI)
Search (use word(s)/phrase)
Table of Contents
By Name
A B C D E F G H I J K L M
N O P Q R S T U V W X Y Z

By CAS Number
Quick Links

General Description

Synonyms: Benzene hexahydride; Hexahydrobenzene; Hexamethylene; Hexanaphthene

OSHA IMIS Code Number: 0810

Chemical Abstracts Service (CAS) Registry Number: 110-82-7

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: GU6300000

Department of Transportation Regulation Number (49 CFR 172.101) and 2012 Emergency Response Guidebook [4 MB PDF, 392 pages]: 1145 128

NIOSH Pocket Guide to Chemical Hazards - Cyclohexane: Physical description, chemical properties, potentially hazardous incompatibilities, and more




Exposure Limits and Health Effects

Exposure Limit

Limit Values

HE Codes

Health Factors and Target Organs

OSHA Permissible Exposure Limit (PEL) - General Industry
See 29 CFR 1910.1000 Table Z-1

300 ppm
(1,050 mg/m3) TWA

HE8

Narcosis

HE16

Mild throat and eye irritation

OSHA PEL - Construction Industry
See 29 CFR 1926.55 Appendix A

300 ppm
(1,050 mg/m3) TWA

HE8

Narcosis

HE16

Mild throat and eye irritation

OSHA PEL - Shipyard Employment
See 29 CFR 1915.1000 Table Z-Shipyards

300 ppm
(1,050 mg/m3) TWA

HE8

Narcosis

HE16

Mild throat and eye irritation

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL)

300 ppm
(1,050 mg/m3) TWA

HE7

Dizziness and nausea
Target organs: Central nervous system

HE8

Narcosis

HE16

Mild eye and upper respiratory irritation

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2002)

100 ppm
(334 mg/m3) TWA

HE3

Mild liver and kidney toxicity

HE7

Sedation, neurobehavioral effects
Target organs: Central nervous system

HE8

Narcosis

HE16

Mild throat and eye irritation

CAL/OSHA PEL

300 ppm
(1,050 mg/m3) TWA

 

 

National Toxicology Program (NTP) carcinogenic classification: Not listed

International Agency for Research on Cancer (IARC) carcinogenic classification: Not listed

U.S. Environmental Protection Agency (EPA) carcinogenic classification: Data is inadequate for an assessment of human carcinogenic potential

EPA Inhalation Reference Concentration (RfC): 6 mg/m3

Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): Not established

NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: 1,300 ppm (10% LEL)

Notes on Other Potential Health Effects and Hazards

  1. Vapor/air mixtures are explosive. Heating will cause a rise in pressure and a risk of bursting (NIOSH/IPCS 2008).
  2. Highly flammable (NIOSH/IPCS 2008).
  3. In human volunteers exposed to ~300 ppm of cyclohexane for 8 hours, the major urinary metabolites were 1,2- and 1,4-cyclohexanediol and their glucuronide conjugates. The mean elimination half-lives of these metabolites ranged from 16 to 17 hours (Mráz et al. 1998).  
  4. In contrast, workers exposed to lower airborne levels of cyclohexane from glues (geometric mean: 27 ppm) showed a 16-hour between-shift decrease in urinary cyclohexanol, from 876 to 96 µg/liter, yielding an estimated biological half-life of approximately 5 hours (Yasugi et al. 1994).
  5. EPA reference concentration established based on a two generation laboratory reproductive and developmental toxicity study resulting in reduced body weight in offspring and effects on hearing. (EPA 2003)

Date Last Revised: 11/16/2012

Literature Basis:

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Cyclohexane. 2002.
  • EPA Cyclohexane (CASRN 110-82-7), 2003
  • EPA Toxicological Review of Cyclohexane in Support of IRIS listing, 2003 [476 KB PDF, 87 pages]
  • Kreckmann, KH; Baldwin, JK; Roberts, LG; et al. (2000) Inhalation developmental toxicity and reproduction studies with cyclohexane. Drug Chem Toxicol 23(4):555-73.
  • Mráz, J. Gálová, E., Nohová, H. and Vítková, D.: 1,2- and 1,4-Cyclohexanediol - major urinary metabolites and biomarkers of exposure to cyclohexane, cyclohexanone, and cyclohexanol in humans. Int. Arch. Occup. Environ. Health 71(8): 560-565, 1998.
  • NIOSH: Occupational Health Guideline - Cyclohexane. 1978.
  • NIOSH/IPCS: International Chemical Safety Cards - Cyclohexane. April 10, 2008.
  • Yasugi, T. et al.: Exposure monitoring and health effect studies of workers occupationally exposed to cyclohexane vapor. Int. Arch. Occup. Environ. Health 65(5): 343-350, 1994.

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Carbon disulfide
    alternate analytical solvent: (99:1) Carbon Disulfide:Dimethylformamide
    maximum volume: 5 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 1500 [127 KB PDF, 8 pages])
    method classification: Partially Validated

** All Trademarks are the property of their respective owners.


Accessibility Assistance: Contact the OSHA Directorate of Technical Support and Emergency Management at (202) 693-2300 for assistance accessing PDF materials.