Health Effects: Reproductive Hazard (HE5); Systemic Toxicity (HE3); Suspected human carcinogen, mutagen (HE2)
Affected Organs: Eyes, skin, respiratory system, reproductive system
Chloroprene is an OSHA Select Carcinogen.
EPA's inhalation reference concentration (daily inhalational exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for chloroprene is 7 µg/m3, and EPA's provisional reference dose (RfD) for chloroprene is 0.02 mg/kg/day.
Chloroprene is metabolized by cytochrome P-450 2E1 to reactive epoxide intermediates, including enantiomers of (1-chloroethenyl)oxirane, which can form adducts with glutathione, hemoglobin, and DNA. No reports of using any of these adducts as markers for occupational exposure to chloroprene were found.
Anemia has been reported to occur in Fischer 344 rats exposed subchronically to 200 ppm chloroprene, as well as in employees occupationally exposed to unreported levels of chloroprene.
Hurst, H.E. and Ali, M.Y.: Analyses of (1-chloroethenyl)oxirane headspace and hemoglobin N-valine adducts in erythrocytes indicate selective detoxification of (1-chloroethenyl)oxirane enantiomers. Chem. Biol. Interact.166(1-3): 332-340, 2007.
Munter, T., Cottrell, L., Ghai, R., Golding, B.T. and Watson, W.P.: The metabolism and molecular toxicology of chloroprene. Chem. Biol. Interact.166(1-3): 323-331, 2007.
No Author: Chloroprene (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Pohanish, R.P. (editor): Chloroprene. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 591-593.
Sanotskii, I.V.: Aspects of the toxicology of chloroprene: immediate and long-term effects. Environ. Health Perspect.17: 85-93, 1976.
Valentine, R. and Himmelstein, M.W.: Overview of the acute, subchronic, reproductive, developmental and genetic toxicology of beta-chloroprene. Chem. Biol. Interact.135-136: 81-100, 2001.
All other documents, that are not PDF materials or formatted for the web, are available as Microsoft Office® formats and videos and are noted accordingly. If additional assistance is needed with reading, reviewing or accessing these documents or any figures and illustrations, please also contact OSHA's Directorate of Technical Support and Emergency Management at (202) 693-2300.
**eBooks - EPUB is the most common format for e-Books. If you use a Sony Reader, a Nook, or an iPad you can download the EPUB file format. If you use a Kindle, you can download the MOBI file format.
U.S. Department of Labor | Occupational Safety & Health Administration | 200 Constitution Ave., NW, Washington, DC 20210 Telephone: 800-321-OSHA (6742) | TTY www.OSHA.gov
Thank You for Visiting Our Website
You are exiting the Department of Labor's Web server.
The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Users must request such authorization from the sponsor of the linked Web site. Thank you for visiting our site. Please click the button below to continue.