alpha-Chloroacetophenone

General Description

  • Synonyms: Phenacyl chloride; omega-Chloroacetophenone; Chloromethyl phenyl ketone; Phenyl chloromethyl ketone; Tear gas; CN; Phenacylchloride
  • OSHA IMIS Code Number: 0618
  • Chemical Abstracts Service (CAS) Registry Number: 532-27-4
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AM6300000; 3237
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: UN1697 Poison
  • Chemical Description and Physical Properties:
    • colorless to gray solid with a sharp, irritating odor
    • molecular weight: 154
    • vapor pressure: 0.012 mm
    • boiling point: 477°F
    • melting point: 138°F

Incompatibilities: water, steam

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
    • General Industry: 0.05 ppm, 0.3 mg/m3
    • Construction Industry: 0.05 ppm, 0.3 mg/m3 TWA
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.05 ppm, 0.32 mg/m3 TWA; Appendix A4 (Not Classifiable as a Human Carcinogen) (TLV listed for 2-Chloroacetophone)
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.05 ppm TWA

Health Factors

  • Potential Symptoms: Eye, skin, respiratory system irritation; pulmonary edema
  • Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14)
  • Affected Organs: Eyes, skin, respiratory system

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Silica Gel Tube (100/50 mg sections; 20/40 mesh)
  • analytical solvent: Ethanol
  • maximum volume: 10 Liters
  • maximum flow rate: 0.1 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/UL59
  • method reference: OSHA PV2182
  • method classification: Partially Validated

Conditions: Column: Zorbax ODS (25cm x 4.6mm) Mobile Phase: 60:40 Methanol:Water with 0.1% H3PO4, 0.1% Di-n-butylamine

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