- Synonyms: Sodium p-Toluenesulfochloramine; para-Toluene Chlorosulfonamide Acid; Chloramine T Trihydrate; n-Sodium, n-chloro, -para-toluene Sulfonamide; Sodium p-Toluenesulfonchloramide Trihydrate
- OSHA IMIS Code Number: C327
- Chemical Abstracts Service (CAS) Registry Number: 127-65-1
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: XT5616800
- Chemical Description and Physical Properties:
- white or slightly yellow crystals or powder, slight chlorine odor. Soluble in water, insoluble in benzene, chloroform and ether. Decomposes slowly in air, liberating chlorine. Decomposes violently at 130°C
- molecular weight: 228.66
- molecular formula: C7 H8 Cl N O2 SNa
- Potential Symptoms: Eye irritation, pain, conjunctivitis; burning sensation, coughing, wheezing, laryngitis, sore throat; rhinitis; dyspnea (shortness of breath), bronchitis, pneumonitis, possible pulmonary edema; allergic asthma; skin redness, itching, pain; nausea, vomiting, diarrhea.
- Health Effects: Respiratory sensitization---asthma (HE9); Skin irritation: allergic urticaria; Ingestion Acute: gastrointestinal irritation.
- Affected Organs: Eyes, respiratory system, skin
- Approved in Europe as an antiseptic for many medical, dental, and veterinary uses, although major market in U.S. is use in whirlpool baths.
- FDA approval of chloramine-T for use in aquaculture (fish farming) in the U.S. is being sought (INAD #8086).
- Haneke, K.E.: Chloramine-T [127-65-1] and Metabolite p-Toluenesulfonamide [70-55-3]: Review of Toxicological Literature (PDF). February 2002, 76 pp.
- (rhinitis) Piirilä, P., Hodgson, U., Estlander, T., Keskinen, H., Saalo, A., Voutilainen, R. and Kanerva, L.: Occupational respiratory hypersensitivity in dental personnel. Int. Arch. Occup. Environ. Health 75: 209-216, 2002.
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Polyvinylchloride (PVC) Filter (37mm)
- maximum volume: 100 Liters
- maximum flow rate: 1 L/min
- current analytical method: High Performance Liquid Chromatograph; HPLC/UV
- analytical solvent: Deionized Water
- method reference: 2 (OSHA In-House File)
- method classification: Not Validated
- note: Protect samples from light.
Column: CN; Mobile Phase: 70:30:0.2 H2O: Acetonitrile: H3PO4; Detector: UV-254nm
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