- Synonyms: 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester methyl carbamic acid; 2,3-Dihydro-2,2-dimethyl-7-benzofuranyl Methyl Carbamate; Crisfuran®; Furacarb®; Furadan®; Pillarfuran®; Yalox®
- OSHA IMIS Code Number: 0526
- Chemical Abstracts Service (CAS) Registry Number: 1563-66-2
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: FB9450000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2757 151
- NIOSH Pocket Guide to Chemical Hazards, Carbofuran: chemical description, physical properties, potentially hazardous incompatibilities, and more
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 mg/m3 TWA (Inhalable Fraction) (Vapor and Aerosol); Appendix A4 - Not Classifiable as a Human Carcinogen; BEI
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.1 mg/m3 TWA
- Potential Symptoms: Miosis, blurred vision, tearing; excessive respiratory secretions; salivation; sweating; abdominal cramps, headache, nausea, vomiting, diarrhea; light-headedness; lassitude (weakness, exhaustion); chest tightness, epigastric pain, labored breathing; cyanosis; muscle twitching; incoordination; convulsions; unconsciousness; respiratory failure; skin irritation; possible effects on the immune system.
- Health Effects: Cholinesterase inhibition (HE6)
- Affected Organs: CNS, peripheral nervous system, blood cholinesterase
- OSHA has not established a PEL for carbofuran.
- Although acute occupational intoxications by carbofuran have been reported, only one case of delayed neuropathy (following an attempted suicide) has been reported.
- Carbofuran effects on the immune system, such as suppression of T-cell-mediated immune responses, were observed in studies with mice.
- NIOSH Pocket Guide to Chemical Hazards: Carbofuran.
- International Chemical Safety Cards (WHO/IPCS/ILO): Carbofuran.
- FMC Corporation: Furadan® 4 F Insecticide/Nematicide (PDF). Material Safety Data Sheet. April 2003.
- Huang, J., Zhang, S., Ding, M., Zhou, A., Zhang, J., Zhang, J.: Acute effects of carbofuran in workers of two pesticide plants. Med. Lav. 89(Suppl. 2): S105-111, 1998.
- Jeon, S.D., Lim, J.S. and Moon, C.K.: Carbofuran suppresses T-cell-mediated immune responses by the suppression of T-cell responsiveness, the differential inhibition of cytokine production, and NO production in macrophages. Toxicol. Lett. 119(2): 143-155, 2001.
- Pohanish, R.P. (editor): Carbofuran. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 486-488.
- Yang, P.Y., Tsao, T.C., Lin, J.L., Lyu, R.K. and Chiang, P.C.: Carbofuran-induced delayed neuropathy. J. Toxicol. Clin. Toxicol. 38(1): 43-46, 2000.
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- OSHA Versatile Sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg sections, 20/60 mesh) with Glass Fiber Filter enclosed
- maximum volume: 480 Liters
- maximum flow rate: 1.0 L/min
- current analytical method: High Performance Liquid Chromatography; HPLC/UV
- analytical solvent: Acetonitrile
- method reference: OSHA Analytical Method (OSHA PV2127)
- method classification: Partially Validated
Wipe Sampling Method:
- Whatman 41 filter paper
- Limit the amount of bulk submitted to one gram or one mL.
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