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Chemical Sampling Information (CSI)
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General Description

Synonyms: 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester methyl carbamic acid; 2,3-Dihydro-2,2-dimethyl-7-benzofuranyl Methyl Carbamate; Crisfuran®; Furacarb®; Furadan®; Pillarfuran®; Yalox®

OSHA IMIS Code Number: 0526

Chemical Abstracts Service (CAS) Registry Number: 1563-66-2

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: FB9450000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2757 151

NIOSH Pocket Guide to Chemical Hazards, Carbofuran: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 mg/m3 TWA (Inhalable Fraction) (Vapor and Aerosol); Appendix A4 - Not Classifiable as a Human Carcinogen; BEI

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.1 mg/m3 TWA

Health Factors

Potential Symptoms: Miosis, blurred vision, tearing; excessive respiratory secretions; salivation; sweating; abdominal cramps, headache, nausea, vomiting, diarrhea; light-headedness; lassitude (weakness, exhaustion); chest tightness, epigastric pain, labored breathing; cyanosis; muscle twitching; incoordination; convulsions; unconsciousness; respiratory failure; skin irritation; possible effects on the immune system.

Health Effects: Cholinesterase inhibition (HE6)

Affected Organs: CNS, peripheral nervous system, blood cholinesterase

Notes:

  1. OSHA has not established a PEL for carbofuran.
  2. Although acute occupational intoxications by carbofuran have been reported, only one case of delayed neuropathy (following an attempted suicide) has been reported.
  3. Carbofuran effects on the immune system, such as suppression of T-cell-mediated immune responses, were observed in studies with mice.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Carbofuran.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Carbofuran.
  • FMC Corporation: Furadan® 4 F Insecticide/Nematicide [24 KB PDF, 7 pages]. Material Safety Data Sheet. April 2003.
  • Huang, J., Zhang, S., Ding, M., Zhou, A., Zhang, J., Zhang, J.: Acute effects of carbofuran in workers of two pesticide plants. Med. Lav. 89(Suppl. 2): S105-111, 1998.
  • Jeon, S.D., Lim, J.S. and Moon, C.K.: Carbofuran suppresses T-cell-mediated immune responses by the suppression of T-cell responsiveness, the differential inhibition of cytokine production, and NO production in macrophages. Toxicol. Lett. 119(2): 143-155, 2001.
  • Pohanish, R.P. (editor): Carbofuran. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 486-488.
  • Yang, P.Y., Tsao, T.C., Lin, J.L., Lyu, R.K. and Chiang, P.C.: Carbofuran-induced delayed neuropathy. J. Toxicol. Clin. Toxicol. 38(1): 43-46, 2000.

Date Last Revised: 05/21/2004

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: OSHA Versatile Sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg sections, 20/60 mesh) with Glass Fiber Filter enclosed
    analytical solvent: Acetonitrile
    maximum volume: 480 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: OSHA Analytical Method (OSHA PV2127)
    method classification: Partially Validated

Wipe Sampling Method:

  • sampling media: Whatman 41 filter paper

Bulk Method:

  • Limit the amount of bulk submitted to one gram or one mL.

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