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Carbofuran

General Description

  • Synonyms: 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester methyl carbamic acid; 2,3-Dihydro-2,2-dimethyl-7-benzofuranyl Methyl Carbamate; Crisfuran®; Furacarb®; Furadan®; Pillarfuran®; Yalox®
  • OSHA IMIS Code Number: 0526
  • Chemical Abstracts Service (CAS) Registry Number: 1563-66-2
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: FB9450000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2757 151
  • NIOSH Pocket Guide to Chemical Hazards, Carbofuran: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 mg/m3 TWA (Inhalable Fraction) (Vapor and Aerosol); Appendix A4 - Not Classifiable as a Human Carcinogen; BEI
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.1 mg/m3 TWA

Health Factors

  • Potential Symptoms: Miosis, blurred vision, tearing; excessive respiratory secretions; salivation; sweating; abdominal cramps, headache, nausea, vomiting, diarrhea; light-headedness; lassitude (weakness, exhaustion); chest tightness, epigastric pain, labored breathing; cyanosis; muscle twitching; incoordination; convulsions; unconsciousness; respiratory failure; skin irritation; possible effects on the immune system.
  • Health Effects: Cholinesterase inhibition (HE6)
  • Affected Organs: CNS, peripheral nervous system, blood cholinesterase
  • Notes:
    1. OSHA has not established a PEL for carbofuran.
    2. Although acute occupational intoxications by carbofuran have been reported, only one case of delayed neuropathy (following an attempted suicide) has been reported.
    3. Carbofuran effects on the immune system, such as suppression of T-cell-mediated immune responses, were observed in studies with mice.
  • Literature Basis:
    • NIOSH Pocket Guide to Chemical Hazards: Carbofuran.
    • International Chemical Safety Cards (WHO/IPCS/ILO): Carbofuran.
    • FMC Corporation: Furadan® 4 F Insecticide/Nematicide (PDF). Material Safety Data Sheet. April 2003.
    • Huang, J., Zhang, S., Ding, M., Zhou, A., Zhang, J., Zhang, J.: Acute effects of carbofuran in workers of two pesticide plants. Med. Lav. 89(Suppl. 2): S105-111, 1998.
    • Jeon, S.D., Lim, J.S. and Moon, C.K.: Carbofuran suppresses T-cell-mediated immune responses by the suppression of T-cell responsiveness, the differential inhibition of cytokine production, and NO production in macrophages. Toxicol. Lett. 119(2): 143-155, 2001.
    • Pohanish, R.P. (editor): Carbofuran. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 486-488.
    • Yang, P.Y., Tsao, T.C., Lin, J.L., Lyu, R.K. and Chiang, P.C.: Carbofuran-induced delayed neuropathy. J. Toxicol. Clin. Toxicol. 38(1): 43-46, 2000.
  • Date Last Revised: 05/21/2004

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • OSHA Versatile Sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg sections, 20/60 mesh) with Glass Fiber Filter enclosed
  • maximum volume: 480 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/UV
  • analytical solvent: Acetonitrile
  • method reference: OSHA Analytical Method (OSHA PV2127)
  • method classification: Partially Validated
Wipe Sampling Method:
  • Whatman 41 filter paper
Bulk Method:
  • Limit the amount of bulk submitted to one gram or one mL.

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