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Captafol

General Description

  • Synonyms: cis-N-((1,1,2,2-Tetrachloroethyl)thio)-4-cyclo-hexene- 1.2-Dicarboximide; Folcid; Difolatan
  • OSHA IMIS Code Number: 0528
  • Chemical Abstracts Service (CAS) Registry Number: 2425-06-1
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: GW4900000; 28722
  • Chemical Description and Physical Properties:
    • solid
    • molecular weight: 349
    • melting point: 159°-161°C

Exposure Limits

  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 mg/m3 TWA (Skin); Appendix A4 (Not Classifiable as a Human Carcinogen)
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.1 mg/m3 TWA (Skin) Potential Carcinogen

Health Factors

  • Health Effects: Dermatitis (HE3); Suspect Teratogen (HE5) Respiratory sensitization (asthma) (HE9) Mutagen (HE2); LD50 (oral, rat) 6200 mg/kg

Primary Laboratory Sampling/Analytical Method (SLC1):

  • OSHA Versatile Sampler (OVS-2) - 13 mm tube (270/140 mg sections, 20/60 mesh) with Glass Fiber Filter enclosed
  • maximum volume: 240 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: Gas Chromatography; GC/ECD
  • method reference: 2 (OSHA in-house file)
  • method classification: not validated
Wipe Sampling Method:
  • Whatman 41 Filter Paper
Bulk Method:
  • Limit the amount of bulk submitted to one gram or one mL.
Conditions:

Column Capillary DB-5 (10 m x 0.32 mm i.d.) with 1 um film Oven temp 220°C; Ret time 4.2 min; Extraction with methanol gave 84% recovery, GC/ECD

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