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Chemical Sampling Information (CSI)
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General Description

Synonyms: Aminocaproic lactam; epsilon-Caprolactam; Hexahydro-2H-azepin-2-one; 2-Oxohexamethyleneimine

OSHA IMIS Code Number: 0523

Chemical Abstracts Service (CAS) Registry Number: 105-60-2

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: CM3675000

NIOSH Pocket Guide to Chemical Hazards, Caprolactam: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3 TWA, Inhalable Fraction and Vapor (see TLV Booklet); Appendix A5 - Not Suspected as a Human Carcinogen

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1 mg/m3 TWA, 3 mg/m3 STEL

Health Factors

Carcinogenic Classification:

Environmental Protection Agency (EPA): Not classified

International Agency for Research on Cancer (IARC): Group 4 - Probably Not Carcinogenic to Humans [381 KB PDF, 171 pages]

Potential Symptoms: Acute (short-term) exposure may result in irritation and burning of the eyes, nose, throat, and skin. Headaches, malaise, confusion, and nervous irritation after inhalation. Chronic (long-term) exposure may cause peeling of the hands and some eye, nose, and throat irritation.

Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15) CNS Effects (HE7)

Affected Organs: Eyes, nose, throat, skin, CNS

Literature Basis:

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: OSHA Versatile Sampler (OVS-7) - 13 mm XAD-7 tube (270/140 mg sections, 20/60 mesh) with Glass Fiber Filter enclosed
    maximum volume: 100 Liters
    maximum flow rate: 1.0 L/min (TWA)
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: OSHA Analytical Method (OSHA PV2012)
    method classification: Partially Validated

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