- Synonyms: 3-Hydroxybutanoic Acid, beta-Lactone; Hydroxybutyric Acid Lactone; 3-Hydroxybutyric Acid, beta-Lactone; 4-Methyl-2-Oxetanone
- OSHA IMIS Code Number: B427
- Chemical Abstracts Service (CAS) Registry Number: 3068-88-0
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: RQ8050000
- Chemical Description and Physical Properties:
- molecular weight: 86.09
- molecular formula: C4H6O2
- boiling point: 71-73°C
- melting point: -43.5°C
- flash point: 60°C
- Carcinogenic Classification:
- International Agency for Research on Cancer (IARC): Group 2B, possibly carcinogenic to humans
- Potential Symptoms: No symptoms for this chemical are available.
- Health Effects: Known animal carcinogen (HE2); LD50 (oral, rat) is 17 ml/kg.
- Affected Organs: Skin (where applied in animal carcinogenicity studies)
- OSHA does not have a PEL for β-butyrolactone.
- β-Butyrolactone can form adducts with the nucleosides, guanosine, adenosine and cytidine. Adduct formation with DNA and RNA have also been demonstrated.
- β-Butyrolactone is metabolized to 2-hydroxybutyric acid by carboxylesterases in animal tissues from nasal turbinates, trachea, lungs and liver, with specific tissue activity decreasing in the order, rabbit > hamster > rat.
- Literature Basis:
- Dahl, A.R., Miller, S.C. and Petridou-Fischer, J.: Carboxylesterases in the respiratory tracts of rabbits, rats and Syrian hamsters. Toxicol. Lett. 36(2): 129-136, 1987.
- Hemminki, K.: Reactions of beta-propiolactone, beta-butyrolactone and gamma-butyrolactone with nucleic acids. Chem. Biol. Interact. 34(3): 323-331, 1981.
- No authors listed: beta-Butyrolactone. IARC Monogr. Eval. Carcinog. Risks Hum. 71(Pt. 3): 1317-1318, 1999.
- Smyth, H.F., Jr., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A. and Nycum, J.S.: Range-finding toxicity data: List VII. Am. Ind. Hyg. Assoc. J. 30(5): 470-476, 1969.
- Date Last Revised: 05/24/2007
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Charcoal Tube (100/50 mg sections, 20/40 mesh)
- maximum volume: 10 Liters
- maximum flow rate: 1 L/min
- current analytical method: Gas Chromatography; GC/FID
- analytical solvent: (95:5) Methylene Chloride:Methanol
- method reference: OSHA Salt Lake Technical Center In-House File
- method classification: Not Validated
- analytical condition: Samples were received requesting cellosolves and butyrolactone. Phase equilibrium studies looked reasonable and gama-butyrolactone was found and confirmed on the "A" portion of a sample.
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