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Butyl Isocyanate

General Description

  • Synonyms: n-Butyl Isocyanate; BIC
  • OSHA IMIS Code Number: B609
  • Chemical Abstracts Service (CAS) Registry Number: 111-36-4
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: NQ8250000; 44183
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: UN2485 Flammable Liquid
  • Chemical Description and Physical Properties:
    • colorless liquid

Health Factors

  • Health Effects: LD50 (oral, rat) 600 mg/kg

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Coated XAD-7 Tube. Coating is 0.3 mg 1-(2-Pyridyl)Piperazine
  • maximum volume: 15 Liters
  • maximum flow rate: 0.05 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/UL58.
  • analytical solvent: Acetonitrile
  • method reference: 2 (OSHA In-House File)
  • method classification: Partially Validated
  • note: The coated XAD-7 tube must be refrigerated until use.

ACN desorption, HPLC/UV; Zorbax CN column; 25% ACN, 75% water; 0.01 M Ammonium acetate, pH 5.9 with acetic acid; Flouresence 240 nm ex. 370 nm em; uv 254 nm RT 8.6 min; DL 0.3 ng/inj, C/P YC

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