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n-Butyl-2-cyanoacrylate

General Description

  • Synonyms: butyl cyanoacrylate; n-butyl cyanoacrylate; 2-cyano-2-propenoic acid butyl ester; enbucrilate
  • OSHA IMIS Code Number: B444
  • Chemical Abstracts Service (CAS) Registry Number: 6606-65-1
  • Chemical Description and Physical Properties:
    • Clear colorless liquid with a sharp, irritating pungent odor. Insoluble in water.
    • molecular formula: C8H11NO2
    • molecular weight: 153.18
    • boiling point: 68°C
    • density: 0.989 @ 20°C
    • vapor pressure: <0.5 mm @ 20°C
    • flash point: >80°C (closed cap)
  • Incompatibilities: Strong Oxidizing Agents; Strong Acids; Strong Bases; Glass; Highly reactive in water - bonds in seconds.

Health Effects

  • Potential Symptoms: Eye, nose, and throat irritation; coughing; wheezing; laryngitis; shortness of breath
  • Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); CNS effects (HE7)
  • Affected Organs: Eyes, skin, respiratory system, CNS
  • Notes:
    1. OSHA does not have a PEL for n-butyl-2-cyanoacrylate.
    2. n-Butyl-2-cyanoacrylate is used as a medical glue and is a component of an FDA-approved system for the embolization of cerebral arteriovenous malformations prior to their surgical treatment
  • Literature Basis: No authors indicated: TRUFILL® n-Butyl Cyanoacrylate (n-BCA) Liquid Embolic System -- P990040 (Issued September 25, 2000). U.S. Food and Drug Administration Center for Devices and Radiologic Health.
  • Date Last Revised: 01/18/2007

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Coated XAD-7 Tube (80/40 mg sections, 20/60 mesh); coating is Phosphoric Acid.
  • maximum volume: 12 Liters
  • maximum flow rate: 0.1 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/UV
  • analytical solvent: 0.2% (v/v) Phosphoric Acid in Acetonitrile
  • method reference: OSHA Salt Lake Technical Center (SLTC) In-House File
  • method classification: Not Validated
  • note: Samples must be kept at reduced temperature and shipped to lab cold.

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