American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 15 mg/m3 Ceiling; Skin (TLV listed under n-Butylamine)
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 15 mg/m3 Ceiling; Skin (REL listed under n-Butylamine)
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH):300 ppm
Potential Symptoms: Eye, nose, throat irritation; cough, sore throat, shortness of breath, pulmonary edema (may be delayed); dizziness; headache; skin flush, burns, blisters, dermatitis; loss of vision; INGES. ACUTE: Burning sensation, abdominal pain, nausea, vomiting, diarrhea, shock or collapse; SKIN ABS.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Pulmonary edema (HE11)
Affected Organs: Eyes, skin, respiratory system
Vapor/air mixtures of butylamine may be explosive.
Butylamine is considered to be generally recognized as safe when used as a flavoring agent (Flavor and Extract Manufacturers Association number 3130; Joint FAO/WHO Expert Committee on Food Additives number 1582).
In two different strains of mice, sensory irritation occurred at a lower concentration of n-butylamine (121-246 ppm) than did pulmonary irritation (300-362 ppm).
International Chemical Safety Cards (WHO/IPCS/ILO): n-Butylamine.
Pohanish, R.P. (editor): Butyl Amines. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 402-404.
Vinggard, A.M., Nielsen, G.D. and Fries, A.S.: Sensory and pulmonary irritation of inhaled n-butylamine in CF-1 and NMRI mice. Lab. Anim. 23(1): 1-6, 1989.
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