Synonyms: 1-Aminobutane; n-Butylamine
OSHA IMIS Code Number: 0470
Chemical Abstracts Service (CAS) Registry Number: 109-73-9
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: EO2975000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1125 132
NIOSH Pocket Guide to Chemical Hazards, n-Butylamine: chemical description, physical properties, potentially hazardous incompatibilities, and more
OSHA Permissible Exposure Limit (PEL):
General Industry: 29 CFR 1910.1000 Z-1 Table -- 5 ppm, 15 mg/m3 Ceiling; Skin
Construction Industry: 29 CFR 1926.55 Appendix A -- 5 ppm, 15 mg/m3 Ceiling; Skin
29 CFR 1915.1000 Table Z-Shipyards -- 5 ppm, 15 mg/m3 Ceiling; Skin
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 15 mg/m3 Ceiling; Skin (TLV listed under n-Butylamine)
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 15 mg/m3 Ceiling; Skin (REL listed under n-Butylamine)
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 300 ppm
Potential Symptoms: Eye, nose, throat irritation; cough, sore throat, shortness of breath, pulmonary edema (may be delayed); dizziness; headache; skin flush, burns, blisters, dermatitis; loss of vision; INGES. ACUTE: Burning sensation, abdominal pain, nausea, vomiting, diarrhea, shock or collapse; SKIN ABS.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Pulmonary edema (HE11)
Affected Organs: Eyes, skin, respiratory system
- Vapor/air mixtures of butylamine may be explosive.
- Butylamine is considered to be generally recognized as safe when used as a flavoring agent (Flavor and Extract Manufacturers Association number 3130; Joint FAO/WHO Expert Committee on Food Additives number 1582).
- In two different strains of mice, sensory irritation occurred at a lower concentration of n-butylamine (121-246 ppm) than did pulmonary irritation (300-362 ppm).
- NIOSH Pocket Guide to Chemical Hazards: n-Butylamine.
- International Chemical Safety Cards (WHO/IPCS/ILO): n-Butylamine.
- Pohanish, R.P. (editor): Butyl Amines. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 402-404.
- Vinggard, A.M., Nielsen, G.D. and Fries, A.S.: Sensory and pulmonary irritation of inhaled n-butylamine in CF-1 and NMRI mice. Lab. Anim. 23(1): 1-6, 1989.
Date Last Revised: 03/13/2007
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Coated Silica Gel Tube (150/75 mg sections, 20/40 mesh); Coating is H2SO4.
analytical solvent: (50:50) Methanol:Water
minimum volume: 2 Liters
maximum volume: 100 Liters
maximum flow rate: 1.0 L/min (Ceiling)
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (NIOSH 2012 [21 KB PDF, 4 pages])
method classification: Fully Validated
note: OSHA personnel may obtain sampling tubes from the Salt Lake Technical Center.
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