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Butylamine

General Description

  • Synonyms: 1-Aminobutane; n-Butylamine
  • OSHA IMIS Code Number: 0470
  • Chemical Abstracts Service (CAS) Registry Number: 109-73-9
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: EO2975000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 1125 132
  • NIOSH Pocket Guide to Chemical Hazards, n-Butylamine: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 15 mg/m3 Ceiling; Skin (TLV listed under n-Butylamine)
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 15 mg/m3 Ceiling; Skin (REL listed under n-Butylamine)

Health Factors

  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 300 ppm
  • Potential Symptoms: Eye, nose, throat irritation; cough, sore throat, shortness of breath, pulmonary edema (may be delayed); dizziness; headache; skin flush, burns, blisters, dermatitis; loss of vision; INGES. ACUTE: Burning sensation, abdominal pain, nausea, vomiting, diarrhea, shock or collapse; SKIN ABS.
  • Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Pulmonary edema (HE11)
  • Affected Organs: Eyes, skin, respiratory system
  • Notes:
    1. Vapor/air mixtures of butylamine may be explosive.
    2. Butylamine is considered to be generally recognized as safe when used as a flavoring agent (Flavor and Extract Manufacturers Association number 3130; Joint FAO/WHO Expert Committee on Food Additives number 1582).
    3. In two different strains of mice, sensory irritation occurred at a lower concentration of n-butylamine (121-246 ppm) than did pulmonary irritation (300-362 ppm).
  • Literature Basis:
    • NIOSH Pocket Guide to Chemical Hazards: n-Butylamine.
    • International Chemical Safety Cards (WHO/IPCS/ILO): n-Butylamine.
    • Pohanish, R.P. (editor): Butyl Amines. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 402-404.
    • Vinggard, A.M., Nielsen, G.D. and Fries, A.S.: Sensory and pulmonary irritation of inhaled n-butylamine in CF-1 and NMRI mice. Lab. Anim. 23(1): 1-6, 1989.
  • Date Last Revised: 03/13/2007

Primary Laboratory Sampling/Analytical Method (SLC1):

  • Coated Silica Gel Tube (150/75 mg sections, 20/40 mesh); Coating is H2SO4.
  • minimum volume: 2 Liters
  • maximum volume: 100 Liters
  • maximum flow rate: 1.0 L/min (Ceiling)
  • current analytical method: Gas Chromatography; GC/FID
  • analytical solvent: (50:50) Methanol:Water
  • method reference: NIOSH Analytical Method (NIOSH 2012 (PDF))
  • method classification: Fully Validated
  • note: OSHA personnel may obtain sampling tubes from the Salt Lake Technical Center (SLTC).

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