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Chemical Sampling Information (CSI)
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General Description

Synonyms: 1-Aminobutane; n-Butylamine

OSHA IMIS Code Number: 0470

Chemical Abstracts Service (CAS) Registry Number: 109-73-9

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: EO2975000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1125 132

NIOSH Pocket Guide to Chemical Hazards, n-Butylamine: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 5 ppm, 15 mg/m3 Ceiling; Skin

Construction Industry: 29 CFR 1926.55 Appendix A -- 5 ppm, 15 mg/m3 Ceiling; Skin

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 5 ppm, 15 mg/m3 Ceiling; Skin

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 15 mg/m3 Ceiling; Skin (TLV listed under n-Butylamine)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 15 mg/m3 Ceiling; Skin (REL listed under n-Butylamine)

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 300 ppm

Potential Symptoms: Eye, nose, throat irritation; cough, sore throat, shortness of breath, pulmonary edema (may be delayed); dizziness; headache; skin flush, burns, blisters, dermatitis; loss of vision; INGES. ACUTE: Burning sensation, abdominal pain, nausea, vomiting, diarrhea, shock or collapse; SKIN ABS.

Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Pulmonary edema (HE11)

Affected Organs: Eyes, skin, respiratory system

Notes:

  1. Vapor/air mixtures of butylamine may be explosive.
  2. Butylamine is considered to be generally recognized as safe when used as a flavoring agent (Flavor and Extract Manufacturers Association number 3130; Joint FAO/WHO Expert Committee on Food Additives number 1582).
  3. In two different strains of mice, sensory irritation occurred at a lower concentration of n-butylamine (121-246 ppm) than did pulmonary irritation (300-362 ppm).

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: n-Butylamine.
  • International Chemical Safety Cards (WHO/IPCS/ILO): n-Butylamine.
  • Pohanish, R.P. (editor): Butyl Amines. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 402-404.
  • Vinggard, A.M., Nielsen, G.D. and Fries, A.S.: Sensory and pulmonary irritation of inhaled n-butylamine in CF-1 and NMRI mice. Lab. Anim. 23(1): 1-6, 1989.

Date Last Revised: 03/13/2007

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Coated Silica Gel Tube (150/75 mg sections, 20/40 mesh); Coating is H2SO4.
    analytical solvent: (50:50) Methanol:Water
    minimum volume: 2 Liters
    maximum volume: 100 Liters
    maximum flow rate: 1.0 L/min (Ceiling)
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 2012 [21 KB PDF, 4 pages])
    method classification: Fully Validated
    note: OSHA personnel may obtain sampling tubes from the Salt Lake Technical Center.

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