US Dept of Labor

Occupational Safety & Health AdministrationWe Can Help

1-Butoxy-2-propanol

General Description

  • Synonyms: IAQ; Propasol Solvent B; Propylene Glycol n-Butyl Ether
  • OSHA IMIS Code Number: B145
  • Chemical Abstracts Service (CAS) Registry Number: 5131-66-8
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UA7700000
  • Chemical Description and Physical Properties:
    • clear colorless liquid, with characteristic odor
    • molecular weight: 132.23
    • vapor pressure: 0.187 kPa @ 25°C
    • molecular formula: C7H16O2
    • boiling point: 170.2°C
    • melting point: -80°C

Health Factors

  • Potential Symptoms: Eye, skin irritation; in animals, high systemic doses caused CNS depression (lethargy, coma), gasping respiration; dacryorrhea (excessive tears), anemia, enlarged livers (with no histologic lesions; reversible) and kidney damage
  • Health Effects: Irritation-Eye, Skin---Mild (HE16); Kidney damage (HE3); Nervous system disturbances---Narcosis (HE8); Lung edema (HE11)
  • Affected Organs: Kidneys, respiratory system, eyes, skin, CNS
  • Notes:
    1. OSHA does not have a PEL for 1-butoxy-2-propanol.
    2. It is a metabolite of dipropylene glycol n-butyl ether and further metabolized by O-dealkylation to propylene glycol and butanol (metabolized to carbon dioxide) or by conjugation with sulfate or glucuronide for urinary excretion.
    3. Repeated-dose inhalational studies in rats indicated a NOAEL of 700 ppm (the maximum attainable concentration in air).
  • Literature Basis:
    • NIOSH Registry of Toxic Effects of Chemical Substances, RTECS #: UA7700000: 2-Propanol, 1-butoxy-.
    • Verschuuren, H.G.: Toxicological studies with propylene glycol n-butyl ether. Occupational Hygiene 2(1-6): 311-318, 1996.
  • Date Last Revised: 05/12/2005

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Tenax Tube
  • maximum volume: 30 Liters
  • maximum flow rate: 0.2 L/min
  • current analytical method: Gas Chromatography; GC/FID
  • method reference: OSHA Salt Lake Technical Center (SLTC) In-House File
  • method classification: Not Validated

Articles: McJilton, C.E.; S.J. Reynolds; A.J. Streifel; R.L.; Pearson. AIHAJ 51(10), p 545-549, 1990.

** All Trademarks are the property of their respective owners.

Search Chemical Sampling Information

Index

By Name

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

By CAS Number
collage image - OSHA Salt Lake Technical Center
Back to Top

Thank You for Visiting Our Website

You are exiting the Department of Labor's Web server.

The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Users must request such authorization from the sponsor of the linked Web site. Thank you for visiting our site. Please click the button below to continue.

Close