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Chemical Sampling Information (CSI)
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General Description

Synonyms: IAQ; Propasol Solvent B; Propylene Glycol n-Butyl Ether

OSHA IMIS Code Number: B145

Chemical Abstracts Service (CAS) Registry Number: 5131-66-8

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UA7700000

Chemical Description and Physical Properties:

clear colorless liquid, with characteristic odor
molecular weight: 132.23
vapor pressure: 0.187 kPa @ 25°C
molecular formula: C7H16O2
boiling point: 170.2°C
melting point: -80°C

Health Factors

Potential Symptoms: Eye, skin irritation; in animals, high systemic doses caused CNS depression (lethargy, coma), gasping respiration; dacryorrhea (excessive tears), anemia, enlarged livers (with no histologic lesions; reversible) and kidney damage

Health Effects: Irritation-Eye, Skin---Mild (HE16); Kidney damage (HE3); Nervous system disturbances---Narcosis (HE8); Lung edema (HE11)

Affected Organs: Kidneys, respiratory system, eyes, skin, CNS

Notes:

  1. OSHA does not have a PEL for 1-butoxy-2-propanol.
  2. It is a metabolite of dipropylene glycol n-butyl ether and further metabolized by O-dealkylation to propylene glycol and butanol (metabolized to carbon dioxide) or by conjugation with sulfate or glucuronide for urinary excretion.
  3. Repeated-dose inhalational studies in rats indicated a NOAEL of 700 ppm (the maximum attainable concentration in air).

Literature Basis:

  • NIOSH Registry of Toxic Effects of Chemical Substances, RTECS #: UA7700000: 2-Propanol, 1-butoxy-.
  • Verschuuren, H.G.: Toxicological studies with propylene glycol n-butyl ether. Occupational Hygiene 2(1-6): 311-318, 1996.

Date Last Revised: 05/12/2005

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Tenax Tube
    maximum volume: 30 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Salt Lake Technical Center In-House File
    method classification: Not Validated

Articles: McJilton, C.E.; S.J. Reynolds; A.J. Streifel; R.L.; Pearson. AIHAJ 51(10), p 545-549, 1990.

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