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General Description

  • Synonyms: IAQ; Propasol Solvent B; Propylene Glycol n-Butyl Ether
  • OSHA IMIS Code Number: B145
  • Chemical Abstracts Service (CAS) Registry Number: 5131-66-8
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UA7700000
  • Chemical Description and Physical Properties:
    • clear colorless liquid, with characteristic odor
    • molecular weight: 132.23
    • vapor pressure: 0.187 kPa @ 25°C
    • molecular formula: C7H16O2
    • boiling point: 170.2°C
    • melting point: -80°C

Health Factors

  • Potential Symptoms: Eye, skin irritation; in animals, high systemic doses caused CNS depression (lethargy, coma), gasping respiration; dacryorrhea (excessive tears), anemia, enlarged livers (with no histologic lesions; reversible) and kidney damage
  • Health Effects: Irritation-Eye, Skin---Mild (HE16); Kidney damage (HE3); Nervous system disturbances---Narcosis (HE8); Lung edema (HE11)
  • Affected Organs: Kidneys, respiratory system, eyes, skin, CNS
  • Notes:
    1. OSHA does not have a PEL for 1-butoxy-2-propanol.
    2. It is a metabolite of dipropylene glycol n-butyl ether and further metabolized by O-dealkylation to propylene glycol and butanol (metabolized to carbon dioxide) or by conjugation with sulfate or glucuronide for urinary excretion.
    3. Repeated-dose inhalational studies in rats indicated a NOAEL of 700 ppm (the maximum attainable concentration in air).
  • Literature Basis:
    • NIOSH Registry of Toxic Effects of Chemical Substances, RTECS #: UA7700000: 2-Propanol, 1-butoxy-.
    • Verschuuren, H.G.: Toxicological studies with propylene glycol n-butyl ether. Occupational Hygiene 2(1-6): 311-318, 1996.
  • Date Last Revised: 05/12/2005

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Charcoal Tube (100/50 mg sections, 20/40 mesh)
  • analytical solvent: Methylene Chloride/Methanol (95/5)
  • maximum volume: 10 Liters
  • maximum flow rate: 0.1 L/min
  • current analytical method: Gas Chromatography; GC/FID
  • method reference: OSHA Salt Lake Technical Center (SLTC) In-House File
  • method classification: Not Validated

McJilton, C.E.; S.J. Reynolds; A.J. Streifel; R.L.; Pearson. AIHAJ 51(10), p 545-549, 1990.

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