OSHA does not have a PEL for 2-bromopropane. South Korea recommended an occupational exposure level of 1 ppm as a TWA on the basis of occupational studies in South Korea, China and Japan.
The two major urinary metabolites of 2-bromopropane, acetone and bromide ion, are normal constituents of urine and might not be useful for monitoring low levels of occupational exposure.
NTP's Center for the Evaluation of Risks to Human Reproduction has expressed some concern for adverse reproductive effects (e.g., decreased sperm count and motility; amenorrhea) at the upper end of reported human occupational exposures in the U.S. to 2-bromopropane (<0.004 to 1.35 ppm), which occur secondarily to its contamination of 1-bromopropane. In other countries where 2-bromopropane is used directly, occupational exposures at higher levels have been reported up to110.8 ppm in breathing zone samples and 16.18 ppm (8-hour TWA) in personal air samples.
Ichihara, G.: Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane. Int. Arch. Occup. Environ. Med. 78(2): 79-96, 2005.
Ichihara, G., et al.: Occupational health survey on workers exposed to 2-bromopropane at low concentrations. Am. J. Ind. Med. 35(5): 523-531, 1999.
Park, J.-S., Kim, Y., Park, D.W., Choi, K.S. Park, S.-H. and Moon, Y.-H.: An outbreak of hematopoietic and preproductive disorders due to solvents containing 2-bromopropane in an electronic factory, South Korea: Epidemiological survey. J. Occup. Health39(2): 138-143, 1997.
Pohanish, R.P. (editor): Bromopropane. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 380-381.
Yu, I.J., Kim, H.Y., Lim, C.H., Lee, Y.M. and Moon, Y.H.: The occupational exposure level (OEL) for 2-bromopropane: the first OEL established by Korea. Appl. Occup. Environ. Hyg. 14(6): 356-358, 1999.
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