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2-Bromopropane

General Description

  • Synonyms: Isopropyl bromide
  • OSHA IMIS Code Number: R289
  • Chemical Abstracts Service (CAS) Registry Number: 75-26-3
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: TX4111000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2344 129
  • Chemical Description and Physical Properties:
    • clear, colorless to slightly yellow flammable liquid
    • molecular weight: 123.01
    • vapor pressure: 31.5 kPa @ 25°C
    • molecular formula: C3H7Br
    • boiling point: 59.0°C
    • melting point: -89°C
    • flash point: 22°C closed cup

Health Factors

  • Potential Symptoms: Eye, skin irritation; dizziness, lightheadedness, unconsciousness; anemia, amenorrhea (in females); oligospermia, azospermia (in males).
  • Health Effects: Irritation-Eye Nose, Throat, Skin---Mild (HE16); Reproductive impairment (HE5); Hematologic disturbances (HE12); Narcosis (HE8).
  • Affected Organs: Eyes, skin, reproductive system, CNS
  • Notes:
    1. OSHA does not have a PEL for 2-bromopropane. South Korea recommended an occupational exposure level of 1 ppm as a TWA on the basis of occupational studies in South Korea, China and Japan.
    2. The two major urinary metabolites of 2-bromopropane, acetone and bromide ion, are normal constituents of urine and might not be useful for monitoring low levels of occupational exposure.
    3. NTP's Center for the Evaluation of Risks to Human Reproduction has expressed some concern for adverse reproductive effects (e.g., decreased sperm count and motility; amenorrhea) at the upper end of reported human occupational exposures in the U.S. to 2-bromopropane (<0.004 to 1.35 ppm), which occur secondarily to its contamination of 1-bromopropane. In other countries where 2-bromopropane is used directly, occupational exposures at higher levels have been reported up to110.8 ppm in breathing zone samples and 16.18 ppm (8-hour TWA) in personal air samples.
  • Literature Basis:
    • National Toxicology Program: NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 2-Bromopropane (2-BP) (PDF).
    • Ichihara, G.: Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane. Int. Arch. Occup. Environ. Med. 78(2): 79-96, 2005.
    • Ichihara, G., et al.: Occupational health survey on workers exposed to 2-bromopropane at low concentrations. Am. J. Ind. Med. 35(5): 523-531, 1999.
    • Park, J.-S., Kim, Y., Park, D.W., Choi, K.S. Park, S.-H. and Moon, Y.-H.: An outbreak of hematopoietic and preproductive disorders due to solvents containing 2-bromopropane in an electronic factory, South Korea: Epidemiological survey. J. Occup. Health 39(2): 138-143, 1997.
    • Pohanish, R.P. (editor): Bromopropane. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 380-381.
    • Yu, I.J., Kim, H.Y., Lim, C.H., Lee, Y.M. and Moon, Y.H.: The occupational exposure level (OEL) for 2-bromopropane: the first OEL established by Korea. Appl. Occup. Environ. Hyg. 14(6): 356-358, 1999.
  • Date Last Revised: 06/12/2007

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Coconut shell charcoal (CSC) tube (6-mm o.d., 100/50-mg sections)
  • maximum volume: 12 Liters
  • maximum flow rate: 0.05 L/min
  • maximum time: 240 Minutes
  • current analytical method: Gas chromatography; GC/ECD
  • analytical solvent: (99:1) Carbon disulfide (CS2):Dimethylformide (DMF)
  • method reference: OSHA Analytical Method (OSHA 1017)
  • method classification: Fully Validated
  • Coconut shell charcoal (CSC) tube (6-mm o.d., 100/50-mg sections)
  • maximum volume: 12 Liters
  • maximum flow rate: 0.1 L/min
  • maximum time: 120 Minutes
  • current analytical method: Gas chromatography; GC/FID
  • analytical solvent: (99:1) Carbon disulfide (CS2):Dimethylformide (DMF)
  • method reference: OSHA Analytical Method (OSHA PV2062)
  • method classification: Partially Validated

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