The odor threshold for bromoform (1.3 ppm) is greater than its PEL.
CNS depressant effects of bromoform may be due to a potentiation of the activity of GABA(A) receptors.
Bromoform is more permeable through human skin in vitro than is chloroform.
EPA's reference dose (RfD) for oral exposure to bromoform is 0.02 mg/kg/day.
Although bromoform can be metabolized to carbon monoxide, breath analysis of parent compound has been recommended as a biological index of occupational exposure to the trihalomethanes.
In the early 1900s, bromoform was used as a sleeping aid for children with whooping cough.
NIOSH Pocket Guide to Chemical Hazards: Bromoform.
International Chemical Safety Cards (WHO/IPCS/ILO): Bromoform.
EPA Air Toxics Website: Bromoform. U.S. Environmental Protection Agency Technology Transfer Network.
Fantuzzi, G., Righi, E., Predieri, G., Ceppelli, G., Gobba, F. and Aggassotti, G.: Occupational exposure to trihalomethanes in indoor swimming pools. Sci. Total Environ. 264(3): 257-265, 2001.
Kash, T.L., Jenkins, A. and Harrison, N.L.: Molecular volume determines the activity of the halogenated alkane bromoform at wild-type and mutant GABA(A) receptors. Brain Res. 960(1-2): 36-41, 2003.
Pohanish, R.P. (editor): Bromoform. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 377-379.
Anders, M.W., Stevens, J.L., Sprague, R.W., Shaath, Z. and Ahmed, A.E.: Metabolism of haloforms to carbon monoxide. II. In vivo studies. Drug Metab. Dispos. 6(5): 556-560, 1978.
Xu, X., Mariano, T.M., Laskin, J.D. and Weisel, C.P.: Percutaneous absorption of trihalomethanes, haloacetic acids, and haloketones. Toxicol. Appl. Pharmacol. 184(1): 19-26, 2002.
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