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Benzo [a] Pyrene

General Description

Synonyms: BaP; 1,2-Benzpyrene; 3,4-BP; 3,4-Benzo(a)pyrene; 4,5-Benzpyrene; 6,7-Benzopyrene; Benzo(d,e,f)chrysene; B(a)P; BaP

OSHA IMIS code: 0726 (Benzo (alpha) Pyrene prior to 3/9/07)

CAS number: 50-32-8

Exposure Limits and Health Effects (Updated September 6, 2012)

Standard Set By Exposure Limit Health Effect Codes -- Health Effects and Target Organs
OSHA PEL - General Industry
See 29 CFR 1910.1000 Table Z-1
See Coal Tar Pitch Volatiles
OSHA PEL - Construction Industry
See 29 CFR 1926.55 Appendix A
See Coal Tar Pitch Volatiles
OSHA PEL - Shipyard Employment
See 29 CFR 1915.1000 Table Z - Shipyards
See Coal Tar Pitch Volatiles
NIOSH REL See Coal Tar Pitch Volatiles
ACGIH TLV® (1990) Exposure by all routes should be controlled to levels as low as possible.
A2
BEI®
HE2 -- cancer
CAL/OSHA PELs See Coal Tar Pitch Volatiles

Carcinogenic classification:

EPA Inhalation Reference Concentration (RfC): Not established

ATSDR Inhalation Minimal Risk Levels (MRLs): Not established

NIOSH IDLH concentration: Not established

Notes on other potential health effects and hazards:

  1. Occupational exposure to benzo(a)pyrene may increase the risk of pancreatic, stomach, and laryngeal cancer (IARC 2005; Spinelli et al. 2006; Gibbs and Sevigny 2007; Friesen et al. 2007; Li et al. 2007)
  2. Occupational exposure to benzo(a)pyrene may increase the risk of ischemic heart disease (Burstyn et al. 2005)
  3. Occupational exposure to benzo(a)pyrene may reduce neurobehavioral function (Niu et al. 2010).

Partial reference list:

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Benzo[a]pyrene. 2016.
  • Burstyn I, Kromhout H, Partanen T, Svane O, Langård S, Ahrens W, Kauppinen T, Stücker I, Shaham J, Heederik D, Ferro G, Heikkilä P, Hooiveld M, Johansen C, Randem BG, Boffetta P.: Polycyclic aromatic hydrocarbons and fatal ischemic heart disease. Epidemiology16(6):744-50, November 2005.
  • IARC: Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to HumansSome Non-heterocyclic Polycyclic Aromatic Hydrocarbons and Some Related Industrial Exposures, v 92. 2005.
  • Friesen MC, Demers PA, Spinelli JJ, Lorenzi MF, Le ND: Comparison of two indices of exposure to polycyclic aromatic hydrocarbons in a retrospective aluminium smelter cohort. Occup Environ Med. 64(4):273-8, April 2007.
  • Gibbs GW and Sevigny M: Mortality and cancer experience of Quebec aluminum reduction plant workers, part 4: cancer incidence. J Occup Environ Med. 49(12):1351-66, December 2007.
  • Li D, Day RS, Bondy ML, Sinha R, Nguyen NT, Evans DB, Abbruzzese JL, Hassan MM: Dietary mutagen exposure and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev.16(4):655-61, April 2007.
  • NIOSH/CEC/IPCS: International Chemical Safety CardsBenzo(a)pyrene. October 17, 2005.
  • Niu Q, Zhang H, Li X, Li M. Benzo[a]pyrene-induced neurobehavioral function and neurotransmitter alterations in coke oven workers. Occup Environ Med. 67(7):444-8, July 2010.
  • Spinelli JJ, Demers PA, Le ND, Friesen MD, Lorenzi MF, Fang R, Gallagher RP. Cancer risk in aluminum reduction plant workers (Canada). Cancer Causes Control. 17(7):939-48, September 2006.

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