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Chemical Sampling Information (CSI)
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General Description

Synonyms: Succinamic Acid, 3-Amino-N-(alpha-carboxyphenethyl)-N-methyl Ester; Canderel; L-Phenylalanine, N-L-alpha-Aspartyl, 1-Methyl Ester; Equal; NutraSweet

OSHA IMIS Code Number: R273

Chemical Abstracts Service (CAS) Registry Number: 22839-47-0

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: WM3407000; 79173

Chemical Description and Physical Properties:

molecular weight: 294.34
molecular formula: C14H18N2O5
Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: PTFE Filter (37 mm; 1 micron)
    analytical solvent: 2.062 gm of 1-heptanesulfonic acid sodium salt to 1.0 L of 3:2 acetonitrile : water, adjust pH to 3.0 with H3PO4
    maximum volume: 1200 L
    maximum flow rate: 3 L/min
    current analytical method: High Pressure Liquid Chromatography; HPLC/UV
    method reference: 1 (NIOSH 5031 [18 KB PDF, 4 pages])
    method classification: Partially Validated

Conditions: column: C18, mobile phase: 60% Eluent A 40% Eluent B check method for mix.

Articles: Versella, G. Bagnasco, G. Mangia, A. "Journal of Chromatography" 349 (1985) 83-89 ...Title: Ion-Pair HPLC Analysis of Aspartame and Related Products ...Collection: 1 micron 37 mm PTFE filter with backup pad 1000 L at 2.5 L/min ...Analytical: HPLC C18 RCM Eluent: 60% [2.062 g 1-heptanesulfonic acid sodium salt and 0.45 g monobasic potassium in 1 L of DI water] and 40% [2.062 g 1-heptanesulfonic acid sodium salt in 1 L of 3:2 acetonitrile:water]. Detector: UV at 220 nm Albrecht, William N. Burr, Gregory A. Neumeister, Charles E. "Applied Industrial Hygiene" Vol 4, No 9, 1989, p 217. ...Virtually the same as the above article for sampling and analytical.

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