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Aspartame

General Description

  • Synonyms: Succinamic Acid, 3-Amino-N-(alpha-carboxyphenethyl)-N-methyl Ester; Canderel; L-Phenylalanine, N-L-alpha-Aspartyl, 1-Methyl Ester; Equal; NutraSweet
  • OSHA IMIS Code Number: R273
  • Chemical Abstracts Service (CAS) Registry Number: 22839-47-0
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: WM3407000; 79173
  • Chemical Description and Physical Properties:
    • molecular weight: 294.34
    • molecular formula: C14H18N2O5

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • PTFE Filter (37 mm; 1 micron)
  • analytical solvent: 2.062 gm of 1-heptanesulfonic acid sodium salt to 1.0 L of 3:2 acetonitrile : water, adjust pH to 3.0 with H3PO4
  • maximum volume: 1200 L
  • maximum flow rate: 3 L/min
  • current analytical method: High Pressure Liquid Chromatography; HPLC/UV
  • method reference: 1 (NIOSH 5031 (PDF))
  • method classification: Partially Validated

Conditions: column: C18, mobile phase: 70% Eluent A 40% Eluent B check method for mix.

Articles: Versella, G. Bagnasco, G. Mangia, A. "Journal of Chromatography" 349 (1985) 83-89 ...Title: Ion-Pair HPLC Analysis of Aspartame and Related Products ...Collection: 1 micron 37 mm PTFE filter with backup pad 1000 L at 2.5 L/min ...Analytical: HPLC C18 RCM Eluent: 60% [2.062 g 1-heptanesulfonic acid sodium salt and 0.45 g monobasic potassium in 1 L of DI water] and 40% [2.062 g 1-heptanesulfonic acid sodium salt in 1 L of 3:2 acetonitrile:water]. Detector: UV at 220 nm Albrecht, William N. Burr, Gregory A. Neumeister, Charles E. "Applied Industrial Hygiene" Vol 4, No 9, 1989, p 217. ...Virtually the same as the above article for sampling and analytical.

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