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General Description

  • Synonyms: alpha-Naphthyl thiourea; alpha-Naphthyl thiocarbamide; 1-Naphthyl-thiourea; N(1-Naphthyl)-2-thiourea; Alphanaphthyl Thiourea
  • OSHA IMIS Code Number: 0235
  • Chemical Abstracts Service (CAS) Registry Number: 86-88-4
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: YT9275000; 86993
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: UN1651 153 Poison
  • Chemical Description and Physical Properties:
    • colorless, odorless solid
    • molecular weight: 202
    • vapor pressure: approx. 0 mm
    • boiling point: Decomposes
    • melting point: 388°F
  • Incompatibilities: Strong oxidizers

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
    • General Industry: 0.3 mg/m3
    • Construction Industry: 0.3 mg/m3 TWA
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.3 mg/m3 TWA; Appendix A4 (Not Classifiable as a Human Carcinogen)
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.3 mg/m3 TWA

Health Factors

  • Carcinogenic Classification:
    • International Agency for Research on Cancer (IARC): Group 3, not classifiable as to its carcinogenicity to humans (alpha-Naphthylthiourea)
  • Potential Symptoms: Vomiting; dyspnea; cyanosis; coarse pulmonary rales; mild liver damage
  • Health Effects: Cumulative Endocrine (thyroid and adrenal) damage (HE3) LD50 (oral, rat) 6 mg/kg
  • Skin Irritation: Eczema
  • Affected Organs: Respiratory system

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Polytetrafluoroethylene (FA) Filter, 1.0 micron
  • analytical solvent: Methanol
  • maximum volume: 480 Liters
  • maximum flow rate: 2.0 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/UL58.
  • method reference: 1 (NIOSH S-276)
  • sampling and analytical error: 0.09
  • method classification: Fully Validated
Wipe Sampling Method:
  • Glass Fiber Filter
  • analytical solvent: Dry
Bulk Method:
  • Limit the amount of bulk submitted to one gram or one mL.

column: C18 mobile phase: 50:50 Methanol: Water detector wavelength: 254nm detection limit: 0.13 mg/m3

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