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Antineoplastic drugs

General Description

  • Synonyms: Cyclophosphamide; Daunamycin; Mitomycin C; Streptozotocin; Uracil Mustard
  • OSHA IMIS Code Number: A617
  • Chemical Abstracts Service (CAS) Registry Number: 50-18-0 (Cyclophosphamide); 20830-81-3 (Daunamycin); 50-07-7 (Mitomycin C); 18883-66-4 (Streptozotocin); 66-75-1 (Uracil Mustard)
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: Varies

Health Factors

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Glass Fiber Filter (37 mm)
  • analytical solvent: Water
  • recommended volume: 100 - 1000L
  • recommended flow rate: 2 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/ U
  • note: They state that there is decomposition on the filter when stored and of the analytical standards when prepared in water but the decomposition does not occur with methylene chloride as the solvent.
Article:

Sorsa, L. Pyy; Hakala, E. "Am. Ind Hyg. Assoc. J." 49(6) p 314-17 (1988). Cyclophosphamide is the chemical discussed in the article.

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