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Chemical Sampling Information (CSI)
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General Description

Synonyms: Cyclophosphamide; Daunamycin; Mitomycin C; Streptozotocin; Uracil Mustard

OSHA IMIS Code Number: A617

Chemical Abstracts Service (CAS) Registry Number: 50-18-0 (Cyclophosphamide); 20830-81-3 (Daunamycin); 50-07-7 (Mitomycin C); 18883-66-4 (Streptozotocin); 66-75-1 (Uracil Mustard)

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: Varies

Health Factors

Carcinogenic Classification:

International Agency for Research on Cancer (IARC): Group 1, carcinogenic to humans (Cyclophosphamide) [227 KB PDF, 3 pages] and Group 2B, possibly carcinogenic to humans (Uracil Mustard) [123 KB PDF, 2 pages]

National Toxicology Program (NTP): Known to be a Human Carcinogen (Cyclophosphamide) [208 KB PDF, 2 pages] and Reasonably Anticipated to be Human Carcinogen (Streptozotocin) [223 KB PDF, 1 page]

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Glass Fiber Filter (37 mm)
    analytical solvent: Water
    recommended volume: 100 - 1000L
    recommended flow rate: 2 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/ U
    note: They state that there is decomposition on the filter when stored and of the analytical standards when prepared in water but the decomposition does not occur with methylene chloride as the solvent.

Article: Sorsa, L. Pyy; Hakala, E. "Am. Ind Hyg. Assoc. J." 49(6) p 314-17 (1988). Cyclophosphamide is the chemical discussed in the article.

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