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Anisidine (o,p-Isomers)

General Description

  • Synonyms: o-Methoxyaniline; p-methoxyaniline
  • OSHA IMIS Code Number: 0225
  • Chemical Abstracts Service (CAS) Registry Number(s): 29191-52-4 (Anisidine (mixed isomers)); 90-04-0 (o-Anisidine); 104-94-9 (p-Anisidine)
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: BZ5410000; 8572
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: UN2431 153 Poison
  • Chemical Description and Physical Properties:
    • ortho: colorless to pink liquid with a characteristic amine odor
    • para: light red-brown solid with a characteristic amine odor
    • molecular weight: 123
    • boiling point: 436/470°F
    • vapor pressure: 0.1 mm
    • melting point: 43/137°F
  • Incompatibilities: Strong oxidizers

Exposure Limits

  • OSHA Permissable Exposure Limit (PEL):
    • General Industry: 0.5 mg/m3 TWA (Skin)
    • Construction Industry: 0.5 mg/m3 TWA (Skin)
  • American Conference of Governmental Industrial Hygenists (ACGIH) Threshold Limit Value (TLV) (1979): o-Anisidine, 0.5 mg/m3 TWA, Skin, A3, BEI; p-Anisidine, 0.5 mg/m3 TWA, Skin, A4, BEI
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Isomer specific 0.5 mg/m3 TWA (Skin); Potential Carcinogen o-Anisidine 0.5 mg/m3 TWA (Skin) p-Anisidine

Health Factors

  • Carcinogenic Classification:
    • National Toxicology Programs (NTP): Suspect Human Carcinogen
    • International Agency for Research on Cancer (IARC): Group 2B, possibly carcinogenic to humans (ortho-Anisidine) Group 3, not classifiable as to its carcinogenicity to humans
  • Possible Symptom(s): Headaches, dizziness; cyanosis; RBC Heinz bodies (carcinogenic)
  • Health Effects: Methemoglobinemia (HE13); Cumulative CNS effects (HE7) LD50 (oral, rat) 2000 mg/kg
  • Affected Organs: Blood, kidneys, liver, CVS

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • XAD-2 Tube (150/75 mg sections, 20/50 mesh)
  • analytical solvent: Methanol
  • maximum volume: 320 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/UL58.
  • method reference: 1 (NIOSH 2514)
  • sampling and analytical error: 0.11
  • method classification: Fully Validated
Wipe Sampling Method:
  • Glass Fiber Filter analytical solvent: Isopropanol

column: C18 mobile phase: 35:65 Acetonitrile: Water wavelength: 254 nm detection limit: 0.06 mg/m3

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