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Chemical Sampling Information (CSI)
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General Description

Synonyms: o-Methoxyaniline; p-methoxyaniline

OSHA IMIS Code Number: 0225

Chemical Abstracts Service (CAS) Registry Number: 29191-52-4

Other Chemical Abstracts Service (CAS) Registry Number: 104-94-9; 90-04-0

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: BZ5410000; 8572

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: UN2431 153 Poison

Chemical Description and Physical Properties:

ortho: colorless to pink liquid with a characteristic amine odor
para: light red-brown solid with a characteristic amine odor
molecular weight: 123
boiling point: 436/470°F
vapor pressure: 0.1 mm
melting point: 43/137°F

Incompatibilities: Strong oxidizers

Exposure Limits

OSHA Permissable Exposure Limit (PEL):

    General Industry: 0.5 mg/m3 TWA (Skin)

    Construction Industry: 0.5 mg/m3 TWA (Skin)

American Conference of Governmental Industrial Hygenists (ACGIH) Threshold Limit Value (TLV): 0.1 ppm, 0.5 mg/m3 TWA (Skin)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Isomer specific 0.5 mg/m3 TWA (Skin); Potential Carcinogen o-Anisidine 0.5 mg/m3 TWA (Skin) p-Anisidine

Health Factors

Carcinogenic Classification:

National Toxicology Programs (NTP): Suspect Human Carcinogen

International Agency for Research on Cancer (IARC): Group 2B, possibly carcinogenic to humans (ortho-Anisidine) Group 3, not classifiable as to its carcinogenicity to humans

Possible Symptom(s): Headaches, dizziness; cyanosis; RBC Heinz bodies (carcinogenic)

Health Effects: Methemoglobinemia (HE13); Cumulative CNS effects (HE7) LD50 (oral, rat) 2000 mg/kg

Affected Organs: Blood, kidneys, liver, CVS

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: XAD-2 Tube (150/75 mg sections, 20/50 mesh)
    analytical solvent: Methanol
    maximum volume: 320 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UL58.
    method reference: 1 (NIOSH 2514 [22 KB PDF, 4 pages])
    sampling and analytical error: 0.11
    method classification: Fully Validated

Conditions: column: C18 mobile phase: 35:65 Acetonitrile: Water wavelength: 254 nm detection limit: 0.06 mg/m3

Wipe Sampling Method:

  • sampling media: Glass Fiber Filter
    analytical solvent: Isopropanol
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