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Chemical Sampling Information (CSI)
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General Description

Synonyms: Acetic acid, pentyl ester; Amyl acetic ester; Amyl acetic ether; 1-Pentanol acetate; 1-Pentyl acetate; Pentyl ester of acetic acid; Primary amyl acetate

OSHA IMIS Code Number: 0190

Chemical Abstracts Service (CAS) Registry Number: 628-63-7

NIOSH Registry of Toxic Effects (RTECS) Identification Number: AJ1925000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1104 129

NIOSH Pocket Guide to Chemical Hazards, n-Amyl Acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 100 ppm, 525 mg/m3 TWA

Construction Industry: 29 CFR 1926.55 Appendix A -- 100 ppm, 525 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 100 ppm, 525 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 50 ppm, 266 mg/m3 TWA; 100 ppm, 532 mg/m3 STEL (Listed under Pentyl acetate, All Isomers)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 100 ppm, 525 mg/m3 TWA

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,000 ppm

Potential Symptoms: Irritation of eyes, nose; cough, sore throat; dry skin, dermatitis; headache; possible CNS depression, dizziness, drowsiness, narcosis

Health Effects: Irritation-Eye, Nose, Throat---Moderate (HE15); Narcosis (HE8); Explosive, Flammable (HE18)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes:

  1. Above 25C, explosive vapor/air mixtures may be formed.
  2. The concentration of amyl acetate causing a 50% decrease in the respiratory rate of mice (a measure of sensory irritation) was reported to be 1531 ppm.
  3. Neurotoxicity studies in rats exposed to amyl acetate by inhalation 6 hours/day for at least 65 days reported a NOAEL of at least 1200 ppm (the highest concentration tested).

Date Last Revised: 06/30/2006

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: n-Amyl Acetate.
  • International Chemical Safety Cards (WHO/IPCS/ILO): n-Amyl acetate.
  • Alarie, Y.: Dose-response analysis in animal studies: prediction of human responses. Environ. Health Perspect. 42: 9-13, 1981.
  • Gill, M.W., Tyler, T.R. and Beyrouty, P.C.: Subchronic inhalation neurotoxicity study of amyl acetate in rats. J. Appl. Toxicol. 20(6): 463-469, 2000.
  • Pohanish, R.P. (editor): Amyl Acetates. In, Sittigs Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 199-201.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (99:1) Carbon disulfide:dimethyl formamide
    maximum volume: 24 Liters
    maximum flow rate: 0.1 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA PV2142)
    method classification: Partially Validated

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Carbon disulfide
    maximum volume: 10 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 1450) [107 KB PDF]
    method classification: Fully Validated
    note: Samples must be refrigerated for shipment to laboratory.

On-Site Sampling Techniques/Methods:

  • device: Detector Tube
    manufacturer: Gastec
    model/type: 147
    sampling information: 4 minutes per pump stroke
    upper measurement limit: 200 ppm
    detection limit: 2 ppm
    overall uncertainty: 15% (10-50 ppm) 10% (50-200 ppm)
    method reference: # on-site air secondary (manufacturer)

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