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n-Amyl acetate

General Description

  • Synonyms: Acetic acid, pentyl ester; Amyl acetic ester; Amyl acetic ether; 1-Pentanol acetate; 1-Pentyl acetate; Pentyl ester of acetic acid; Primary amyl acetate
  • OSHA IMIS Code Number: 0190
  • Chemical Abstracts Service (CAS) Registry Number: 628-63-7
  • NIOSH Registry of Toxic Effects (RTECS) Identification Number: AJ1925000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 1104 129
  • NIOSH Pocket Guide to Chemical Hazards, n-Amyl Acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 50 ppm, 266 mg/m3 TWA; 100 ppm, 532 mg/m3 STEL (Listed under Pentyl acetate, All Isomers)
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 100 ppm, 525 mg/m3 TWA

Health Factors

  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,000 ppm
  • Potential Symptoms: Irritation of eyes, nose; cough, sore throat; dry skin, dermatitis; headache; possible CNS depression, dizziness, drowsiness, narcosis
  • Health Effects: Irritation-Eye, Nose, Throat---Moderate (HE15); Narcosis (HE8); Explosive, Flammable (HE18)
  • Affected Organs: Eyes, skin, respiratory system, CNS
  • Notes:
    1. Above 25°C, explosive vapor/air mixtures may be formed.
    2. The concentration of amyl acetate causing a 50% decrease in the respiratory rate of mice (a measure of sensory irritation) was reported to be 1531 ppm.
    3. Neurotoxicity studies in rats exposed to amyl acetate by inhalation 6 hours/day for at least 65 days reported a NOAEL of at least 1200 ppm (the highest concentration tested).
  • Date Last Revised: 06/30/2006
  • Literature Basis:
    • NIOSH Pocket Guide to Chemical Hazards: n-Amyl Acetate.
    • International Chemical Safety Cards (WHO/IPCS/ILO): n-Amyl acetate.
    • Alarie, Y.: Dose-response analysis in animal studies: prediction of human responses. Environ. Health Perspect. 42: 9-13, 1981.
    • Gill, M.W., Tyler, T.R. and Beyrouty, P.C.: Subchronic inhalation neurotoxicity study of amyl acetate in rats. J. Appl. Toxicol. 20(6): 463-469, 2000.
    • Pohanish, R.P. (editor): Amyl Acetates. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 199-201.

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method:
  • Charcoal Tube (100/50 mg sections, 20/40 mesh)
  • maximum volume: 24 Liters
  • maximum flow rate: 0.1 L/min
  • current analytical method: Gas Chromatography; GC/FID
  • analytical solvent: (99:1) Carbon disulfide:dimethyl formamide
  • method reference: OSHA Analytical Method (OSHA PV2142)
  • method classification: Partially Validated
  • Charcoal Tube (100/50 mg sections, 20/40 mesh)
  • maximum volume: 10 Liters
  • maximum flow rate: 0.2 L/min
  • current analytical method: Gas Chromatography; GC/FID
  • analytical solvent: Carbon disulfide
  • method reference: NIOSH Analytical Method (NIOSH 1450 (PDF))
  • method classification: Fully Validated
  • note: Samples must be refrigerated for shipment to laboratory.
On-Site Sampling Techniques/Methods:
  • Detector Tube
  • manufacturer: Gastec
  • model/type: 147
  • sampling information: 4 minutes per pump stroke
  • upper measurement limit: 200 ppm
  • detection limit: 2 ppm
  • overall uncertainty: 15% (10-50 ppm) 10% (50-200 ppm)
  • method reference: # on-site air secondary (manufacturer)

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