- Synonyms: Aminotriazole; 3-Aminotriazole; 2-Amino-1,3,4-triazole; 3-Amino-s-Triazole; 3-Amino-1,2,4-Triazole; 3-Amino-1H-1,2,4-Triazole
- OSHA IMIS Code Number: A176
- IMIS Name History: 3-Amino-s-Triazole prior to 9/1/89
- Chemical Abstracts Service (CAS) Registry Number: 61-82-5
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: XZ3850000
- NIOSH Pocket Guide to Chemical Hazards, Amitrole: chemical description, physical properties, potentially hazardous incompatibilities, and more
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.2 mg/m3 TWA; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Ca 0.2 mg/m3 TWA; Appendix A - NIOSH Potential Occupational Carcinogens
- Carcinogenic Classification:
- Environmental Protection Agency (EPA): Group B2, probable human carcinogen
- International Agency for Research on Cancer (IARC): Group 3, not classifiable as to carcinogenicity to humans (PDF)
- National Toxicology Program (NTP): Group 2, reasonably anticipated to be a human carcinogen (PDF)
- Potential Symptoms: Irritation of eyes, skin; dyspnea, muscle spasms, ataxia, anorexia, salivation, increased body temperature; lassitude (weakness, exhaustion), skin dryness, depression (suppression of thyroid function).
- Health Effects: Hypothyroidism, goiter (HE3); Potential occupational carcinogen (HE2)
- Affected Organs: Eyes, skin, thyroid
- Although OSHA does not have a PEL for amitrole, it is an OSHA Select carcinogen.
- Carcinogenesis studies in rats and mice indicated the occurrence of thyroid, liver, and pituitary tumors.
- Amitrole binds covalently to and inhibits the activity of catalase, an enzyme thought to be involved in ethanol metabolism, inflammation, aging and cancer.
- Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Amitrole.
- International Chemical Safety Cards (WHO/IPCS/ILO): Amitrole.
- Environmental Protection Agency: R.E.D. Facts: Amitrole. Publication No. EPA-738-F-96-002 (August) 1996, 13 pp.
- Hurley, P.M.: Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ. Health Perspect. 106(8): 437-445, 1998.
- Pohanish, R.P. (editor): 3-Amino-1,2,4-Triazole. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 143-144.
- Putnam, C.D., Arvai, A.S., Bourne, Y. and Tainer, J.A.: Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism. J. Mol. Biol. 296(1): 295-309, 2000.
- Date Last Revised: 05/05/2005
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
- Midget Impinger containing 10 mL Distilled Water
- maximum volume: 60 Liters
- maximum flow rate: 1.0 L/min
- current analytical method: High Performance Liquid Chromatography; HPLC/UV
- method reference: OSHA Analytical Method (OSHA PV2006)
- method classification: Partially Validated
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