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3-Aminopyridine

General Description

  • Synonyms: ß-aminopyridine; 3-AP; 3-pyridylamine m-aminopyridine; amino-3-pyridine; ß-pyridylamine
  • OSHA IMIS Code Number: A174
  • Chemical Abstracts Service (CAS) Registry Number: 462-08-8
  • Chemical Description and Physical Properties:
    • white to light yellow-brown crystals with characteristic unpleasant odor
    • molecular formula: C5H6N2
    • molecular weight: 94.13
    • boiling point: 251°C (484°F)
    • flash point: 88°C (190°F) closed cup
    • solubility: soluble in water, alcohol, ether
    • melting point: 64°C (147°F)

Health Factors

  • Potential Symptoms: Irritation of eyes (redness, pain), skin (redness, pain), respiratory tract, and digestive tract; headache, nausea, increased blood pressure, weakness; tremor, excitability, convulsions, stupor.
  • Health Effects: Poisonous (HE4); Convulsions (HE7); Irritation-Eyes, Nose, Throat, Skin---Marked (HE14)
  • Affected Organs: CNS, eyes, skin
  • Notes:
    1. OSHA does not have a PEL for 3-aminopyridine, which may be fatal if absorbed through the skin or swallowed.
    2. 3-Aminopyridine is a potassium channel blocker used as a research tool to induce seizures in experimental animal models of epilepsy.
  • Date Last Revised: 09/19/2006
  • Literature Basis:
    • Acros Organics N.V.: Material Safety Data Sheet: 3-Aminopyridine, 99%.
    • Galvan, M., Franz, P. and Vogel-Weins, C.: Actions of potassium channel blockers on guinea-pig lateral olfactory tract axons. Naunyn-Schmiedebergs Arch. Pharmacol. 325(1): 8-11, 1984.
    • Riker, W.K., Matsumoto, M. and Takashima, K.: Synaptic facilitation by 3-aminopyridine and its antagonism by verapamil and diltiazem. J. Pharmacol. Exp. Ther. 235(2): 431-435, 1985.
    • Slezia, A., et al.: Uridine release during aminopyridine-induced epilepsy. Neurobiol. Dis. 16(3): 490-499, 2004.

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • three-piece cassettes containing two sulfuric acid-treated glass fiber filters separated by a spacer in a closed face cassette
  • analytical solvent: 0.1 N NaOH
  • maximum volume: 240 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: Gas Chromatography; GC/NPD
  • method reference: OSHA Analytical Method (OSHA PV2143)
  • method classification: Partially Validated

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