- Synonyms: ß-aminopyridine; 3-AP; 3-pyridylamine m-aminopyridine; amino-3-pyridine; ß-pyridylamine
- OSHA IMIS Code Number: A174
- Chemical Abstracts Service (CAS) Registry Number: 462-08-8
- Chemical Description and Physical Properties:
- white to light yellow-brown crystals with characteristic unpleasant odor
- molecular formula: C5H6N2
- molecular weight: 94.13
- boiling point: 251°C (484°F)
- flash point: 88°C (190°F) closed cup
- solubility: soluble in water, alcohol, ether
- melting point: 64°C (147°F)
- Potential Symptoms: Irritation of eyes (redness, pain), skin (redness, pain), respiratory tract, and digestive tract; headache, nausea, increased blood pressure, weakness; tremor, excitability, convulsions, stupor.
- Health Effects: Poisonous (HE4); Convulsions (HE7); Irritation-Eyes, Nose, Throat, Skin---Marked (HE14)
- Affected Organs: CNS, eyes, skin
- OSHA does not have a PEL for 3-aminopyridine, which may be fatal if absorbed through the skin or swallowed.
- 3-Aminopyridine is a potassium channel blocker used as a research tool to induce seizures in experimental animal models of epilepsy.
- Acros Organics N.V.: Material Safety Data Sheet: 3-Aminopyridine, 99%.
- Galvan, M., Franz, P. and Vogel-Weins, C.: Actions of potassium channel blockers on guinea-pig lateral olfactory tract axons. Naunyn-Schmiedebergs Arch. Pharmacol. 325(1): 8-11, 1984.
- Riker, W.K., Matsumoto, M. and Takashima, K.: Synaptic facilitation by 3-aminopyridine and its antagonism by verapamil and diltiazem. J. Pharmacol. Exp. Ther. 235(2): 431-435, 1985.
- Slezia, A., et al.: Uridine release during aminopyridine-induced epilepsy. Neurobiol. Dis. 16(3): 490-499, 2004.
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- three-piece cassettes containing two sulfuric acid-treated glass fiber filters separated by a spacer in a closed face cassette
- analytical solvent: 0.1 N NaOH
- maximum volume: 240 Liters
- maximum flow rate: 1.0 L/min
- current analytical method: Gas Chromatography; GC/NPD
- method reference: OSHA Analytical Method (OSHA PV2143)
- method classification: Partially Validated
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