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2-Aminopyridine

General Description

  • Synonyms: alpha-Aminopyridine; alpha-Pyridylamine
  • OSHA IMIS Code Number: 0165
  • Chemical Abstracts Service (CAS) Registry Number: 504-29-0
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: US1575000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2671 153
  • NIOSH Pocket Guide to Chemical Hazards, 2-Aminopyridine: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.5 ppm, 1.9 mg/m3 TWA
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.5 ppm, 2 mg/m3 TWA

Health Factors

  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 5 ppm
  • Potential Symptoms: Irritation of eyes, nose, throat; headache, dizziness; excitement; nausea; high blood pressure; respiratory distress; lassitude (weakness, exhaustion); convulsions; stupor
  • Health Effects: Headache, Increased Blood Pressure (HE4); CNS Stimulation (HE7); Irritation-Eyes, Throat, Skin---Severity undetermined
  • Affected Organs: CNS, respiratory system, eyes, skin
  • Notes:
    1. Absorption of 2-aminopyridine through skin via direct contact is thought to be a possible route of systemic exposure. Its percutaneous LD50 in guinea pigs was reported to be 500 mg/kg of body weight.
    2. Toxic concentrations of 2-aminopyridine may be achieved in air without an odor warning.
  • Literature Basis:
    • NIOSH Pocket Guide to Chemical Hazards: 2-Aminopyridine.
    • NIOSH: The Registry of Toxic Effects of Chemical Substances: Pyridine, 1-amino- (RTECS #: US1575000).
    • International Chemical Safety Cards (WHO/IPCS/ILO): 2-Aminopyridine.
    • Pohanish, R.P. (editor): 2-Aminopyridine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 140-141.
  • Date Last Revised: 08/04/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Three-piece cassettes containing two sulfuric acid-treated glass fiber filters separated by a ring
  • analytical solvent: 0.1 N NaOH
  • maximum volume: 240 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: Gas Chromatography; GC/NPD
  • method reference: OSHA Analytical Method (OSHA PV2143)
  • method classification: Partially Validated
Wipe Sampling Method:
  • Glass Fiber Filter
  • analytical solvent: Isopropanol

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