Synonyms: 1-Aminopropan-2-ol; alpha-Aminoisopropyl alcohol; 2-Hydroxypropylamine; Isopropanolamine; 1-Methyl-2-aminoethanol
OSHA IMIS Code Number: A606
Chemical Abstracts Service (CAS) Registry Number: 78-96-6
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UA5775000
Chemical Description and Physical Properties:
clear liquid with a ammoniacal odor
molecular weight: 75.13
vapor pressure: 0.0013 kPa @ 20°C
molecular formula: C3H9NO
boiling point: 159.9°C
melting point: 1.4°C
77°C (165°F) closed cup
Potential Symptoms: Irritation of eyes, skin, respiratory system; cough, sore throat, shortness of breath, pulmonary edema (may be delayed); skin pain, redness, burns, blisters; eye pain, redness, burns, loss of vision; INGES. ACUTE: Burning sensation; abdominal cramps; shock or collapse.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Pulmonary edema (HE11).
Affected Organs: Skin, eyes, respiratory system
- OSHA does not have a PEL for 1-amino-2-propanol. An occupational exposure limit of 7.3 mg/m3 has been proposed, being 1/60 of the concentration causing a 50% decrease in respiratory frequency due to respiratory irritation in mice exposed for 3 hours.
- Vapor/air mixtures of 1-amino-2-propanol may be explosive at temperatures above 77°C.
- 1-Amino-2-propanol is considered to have no safety concern at current levels of intake when used as a flavoring agent [Flavor and Extract Manufacturers Association number 3130; Joint FAO/WHO Expert Committee on Food Additives (JECFA) number 1582]. JECFA may revoke this status if use levels as a flavoring agent or poundage data remain unknown by the end of 2007.
- Exposure of the skin to a 2% solution may be slightly irritating, but did not cause sensitization in any of 150 volunteers.
- Five cases of irritant contact dermatitis were found during a NIOSH evaluation of some employees exposed to monoisopropanolamine at a plant that produces titanium dioxide pigment.
- International Chemical Safety Cards (WHO/IPCS/ILO): Isopropanolamine.
- Detwiler-Okabayashi, K.A. and Schaper, M.M.: Respiratory effects of a synthetic metalworking fluid and its components. Arch. Toxicol. 70(3-4): 195-201, 1996.
- Geier, J., et al.: Patch testing with components of water-based metalworking fluids: results of a multicentre study with a second series. Contact Dermatitis 55(6): 322-329, 2006.
- Hervin, R.L. and Lucas, J.B.: Occupational Health Case Report No. 8. Monoisopropanolamine. J. Occup. Med. 16(5): 355-357, 1974.
- No authors listed: Summary of Evaluations Performed by the Joint FAO/WHO Expert Committee on Food Additives, 1-Amino-2-propanol.
Date Last Revised: 03/13/2007
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Coated XAD-2 Tube (80/40 sections, 20/60 mesh); coating is 10% (w/w) 1-Naphthylisothiocyanate (NITC)
analytical solvent: Dimethylformamide
maximum volume: 20 Liters
maximum flow rate: 0.1 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: OSHA Analytical Method (OSHA PV2122)
method classification: Partially Validated
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