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4-Aminodiphenyl

General Description

  • Synonyms: p-Aminodiphenyl; 4-Aminobiphenyl
  • OSHA IMIS Code Number: 0162
  • Chemical Abstracts Service (CAS) Registry Number: 92-67-1
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: DU8925000; 20613
  • Chemical Description and Physical Properties:
    • colorless crystals which turn purple on contact with air; floral odor
    • molecular weight: 169
    • boiling point: 575°F
    • melting point: 127°F

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): Appendix A1 (Confirmed Human Carcinogen)
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 29 CFR 1910.1011 Potential Carcinogen

Health Factors

  • Carcinogenic Classification:
  • Potential Symptoms: Headaches, lethargy, dizziness; dyspnea; ataxia, weakness; methemoglobinemia; urinary burning; acute hemorrhage cystitis, (carcinogenic)
  • Health Effects: Cancer---Currently regulated by OSHA as carcinogen; chiefly work practice standards (HE1) LD50 (oral, rat) 500 mg/kg
  • Skin Absorption: Yes
  • Affected Organs: bladder, skin

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Coated Glass Fiber Filters (37 mm) in 3 piece cassette. Coating is Sulfuric Acid.
  • maximum volume: 100 Liters
  • maximum flow rate: 0.1 L/min
  • current analytical method: Gas Chromatography; GC/ECD
  • method reference: 2 (OSHA 93)
  • sampling and analytical error: 0.09
  • method classification: Fully Validated
  • note: Within ten hours after sampling, transfer filter to glass vial containing 2 mL deionized water. Filters may be obtained by OSHA personnel from the Salt Lake Technical Center.
Wipe Sampling Method:
  • Glass Fiber Filter
Bulk Method:
  • Limit the amount of bulk submitted to one gram or one mL.
Conditions:

column: C18 mobile phase: 65% methanol 35% water ultra violet detector: 280nm, 220nm fluoresence detector: excitation: 265nm emissions: 389nm retention time: 8.9 min detection limit: 0.06 ug/sample

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