Allyl glycidyl ether
- Synonyms: AGE; 1-Allyloxy-2,3-epoxypropane; Composite Constituent; Glycidyl allyl ether; [(2-Propenyloxy)methyl] oxirane
- OSHA IMIS Code Number: 0145
- Chemical Abstracts Service (CAS) Registry Number: 106-92-3
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: RR0875000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2219 129
- NIOSH Pocket Guide to Chemical Hazards, Allyl glycidyl ether: chemical description, physical properties, potentially hazardous incompatibilities, and more
- OSHA Permissible Exposure Limit (PEL):
- General Industry: 29 CFR 1910.1000 Z-1 Table -- 10 ppm, 45 mg/m3 Ceiling
- Construction Industry: 29 CFR 1926.55 Appendix A -- 10 ppm, 45 mg/m3
- Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 10 ppm, 45 mg/m3 Ceiling
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1 ppm, 5 mg/m3 TWA; Appendix A4 - Not Classifiable as a Human Carcinogen
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 22 mg/m3 TWA; 10 ppm, 44 mg/m3 STEL; Skin
- NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 50 ppm
- Potential Symptoms: Irritation of eyes, skin, nose, respiratory system; pulmonary edema; narcosis; skin redness, pain, blisters; eye redness, pain, burns, blurred vision; dermatitis; possible hematopoietic, reproductive effects; INGES. ACUTE: Burning sensation, dullness, drowsiness, headache, nausea, vomiting
- Health Effects: Irritation – Eyes, nose, throat, bronchi, skin---Marked (HE14); Mutagenic (HE2)
- Affected Organs: Eyes, skin, respiratory system, blood, reproductive system.
- Vapor/air mixtures of allyl glycidyl ether may be explosive above 48°C.
- Application of 4 mg of allyl glycidyl ether in acetone to the skin of mice resulted in adduct formation with the N-terminal valine in hemoglobin to form N-(2-hydroxy-3-(2,3-dihydroxy)propylvaline.
- Adducts with DNA, primarily at the N-7-guanine and N-1-adenine positions, have also been reported after application of allyl glycidyl ether to the skin of mice.
- Occupational allergic contact dermatitis from allyl glycidyl ether has been reported.
Date Last Revised: 06/25/2007
- NIOSH Pocket Guide to Chemical Hazards: Allyl glycidyl ether.
- International Chemical Safety Cards (WHO/IPCS/ILO): Allyl glycidyl ether.
- Dooms-Goossens, A., Bruze, M., Buysse, L., Fregert, S., Gruvberger, B. and Stals, H.: Contact allergy to allyl glycidyl ether present as an impurity in 3-glycidyloxypropyltrimethoxysilane, a fixing additive in silicone and polyurethane resins. Contact Dermatitis 33(1): 17-19, 1995.
- National Toxicology Program: NTP Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalational Studies). Natl. Toxicol. Program Tech. Rep. Ser. 376: 1-219, 1990.
- Pérez, H.L. and Osterman-Golkar, S.: Biotransformation of the double bond in allyl glycidyl ether to an epoxide ring. Evidence from hemoglobin adducts in mice. Chem. Biol. Interact. 125(1): 17-28, 2000.
- Pina, K. and Segerbäch, D.: 32P-Postlabeling of DNA adducts formed by allyl glycidyl ether in vitro and in vivo. Carcinogenesis 18(8): 1457-1462, 1997.
- Pohanish, R.P. (editor): Allyl Glycidyl Ether. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 101-103.
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Tenax-GC Tube (100/50 mg sections, 35/60 mesh)
- Analytical solvent: Diethyl ether
- maximum volume: 3 Liters
- maximum flow rate: 0.2 L/min (TWA)
- maximum volume: 3 Liters
- maximum flow rate: 0.2 L/min (STEL)
- minimum time: 15 minutes
- maximum flow rate: 0.2 L/min (Ceiling)
- current analytical method: Gas Chromatography; GC/FID
- method reference: NIOSH Analytical Method (NIOSH 2545 (PDF))
- method classification: Fully Validated
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