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Allyl glycidyl ether

General Description

  • Synonyms: AGE; 1-Allyloxy-2,3-epoxypropane; Composite Constituent; Glycidyl allyl ether; [(2-Propenyloxy)methyl] oxirane
  • OSHA IMIS Code Number: 0145
  • Chemical Abstracts Service (CAS) Registry Number: 106-92-3
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: RR0875000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2219 129
  • NIOSH Pocket Guide to Chemical Hazards, Allyl glycidyl ether: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1 ppm, 5 mg/m3 TWA; Appendix A4 - Not Classifiable as a Human Carcinogen
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 22 mg/m3 TWA; 10 ppm, 44 mg/m3 STEL; Skin

Health Factors

  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 50 ppm
  • Potential Symptoms: Irritation of eyes, skin, nose, respiratory system; pulmonary edema; narcosis; skin redness, pain, blisters; eye redness, pain, burns, blurred vision; dermatitis; possible hematopoietic, reproductive effects; INGES. ACUTE: Burning sensation, dullness, drowsiness, headache, nausea, vomiting
  • Health Effects: Irritation – Eyes, nose, throat, bronchi, skin---Marked (HE14); Mutagenic (HE2)
  • Affected Organs: Eyes, skin, respiratory system, blood, reproductive system.
  • Notes:
  1. Vapor/air mixtures of allyl glycidyl ether may be explosive above 48°C.
  2. Application of 4 mg of allyl glycidyl ether in acetone to the skin of mice resulted in adduct formation with the N-terminal valine in hemoglobin to form N-(2-hydroxy-3-(2,3-dihydroxy)propylvaline.
  3. Adducts with DNA, primarily at the N-7-guanine and N-1-adenine positions, have also been reported after application of allyl glycidyl ether to the skin of mice.
  4. Occupational allergic contact dermatitis from allyl glycidyl ether has been reported.

Date Last Revised: 06/25/2007

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Allyl glycidyl ether.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Allyl glycidyl ether.
  • Dooms-Goossens, A., Bruze, M., Buysse, L., Fregert, S., Gruvberger, B. and Stals, H.: Contact allergy to allyl glycidyl ether present as an impurity in 3-glycidyloxypropyltrimethoxysilane, a fixing additive in silicone and polyurethane resins. Contact Dermatitis 33(1): 17-19, 1995.
  • National Toxicology Program: NTP Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalational Studies). Natl. Toxicol. Program Tech. Rep. Ser. 376: 1-219, 1990.
  • Pérez, H.L. and Osterman-Golkar, S.: Biotransformation of the double bond in allyl glycidyl ether to an epoxide ring. Evidence from hemoglobin adducts in mice. Chem. Biol. Interact. 125(1): 17-28, 2000.
  • Pina, K. and Segerbäch, D.: 32P-Postlabeling of DNA adducts formed by allyl glycidyl ether in vitro and in vivo. Carcinogenesis 18(8): 1457-1462, 1997.
  • Pohanish, R.P. (editor): Allyl Glycidyl Ether. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 101-103.

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Tenax-GC Tube (100/50 mg sections, 35/60 mesh)
  • Analytical solvent: Diethyl ether
  • maximum volume: 3 Liters
  • maximum flow rate: 0.2 L/min (TWA)
  • maximum volume: 3 Liters
  • maximum flow rate: 0.2 L/min (STEL)
  • minimum time: 15 minutes
  • maximum flow rate: 0.2 L/min (Ceiling)
  • current analytical method: Gas Chromatography; GC/FID
  • method reference: NIOSH Analytical Method (NIOSH 2545 (PDF))
  • method classification: Fully Validated

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