US Dept of Labor

Occupational Safety & Health AdministrationWe Can Help

Allyl chloride

General Description

  • Synonyms: 3-Chloropropene; 1-Chloro-2-propene; 3-Chloropropylene
  • OSHA IMIS Code Number: 0140
  • Chemical Abstracts Service (CAS) Registry Number: 107-05-1
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UC7350000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 1100 131
  • NIOSH Pocket Guide to Chemical Hazards, Allyl chloride: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1 ppm, 3 mg/m3 TWA; 2 ppm, 6 mg/m3 STEL; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL):1 ppm, 3 mg/m3 TWA; 2 ppm, 6 mg/m3 STEL

Health Factors

  • Carcinogenic Classification:
  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 250 ppm
  • Potential Symptoms: Irritation of eyes, skin, nose, mucous membrane; lacrimation, sneezing, cough, sore throat, labored breathing, pulmonary edema (may be delayed); headache, dizziness, weakness; tingling sensation, coldness, numbness in hands and feet; eye redness, pain, blurred vision; in animals: liver, kidney injury; Ingestion acute: Burning sensation, abdominal pain, vomiting.
  • Health Effects: Irritation- Eye, Nose, Throat---Marked (HE14); Polyneuropathy (HE7); Liver damage (HE3); Mutagen (HE2).
  • Affected Organs: Eyes, skin, respiratory system, peripheral nervous system, liver, kidneys.
  • Notes:
    1. Vapor/air mixtures of Allyl chloride may be explosive.
    2. The major urinary metabolite, 3-hydroxypropylmercapturic acid, has been studied as a biomarker for occupational exposure to Allyl chloride, and an 8-hour biological exposure index of 352 µg/gram creatinine has been proposed. However, garlic consumption may interfere with an accurate determination of occupational exposure.
    3. This metabolite is not specific for Allyl chloride, as it may also be produced from allyl alcohol, allyl formate (and other allyl esters), allyl nitrate, and acrolein.
    4. Mechanistic studies of neurochemical changes in rats gavaged with Allyl chloride in corn oil (200 mg/kg, 3 times/week for 12 weeks) indicated toxic effects in the CNS as well as in the peripheral nervous system.
  • Date Last Revised: 06/26/2007
  • Literature Basis:
    • NIOSH Pocket Guide to Chemical Hazards: Allyl chloride.
    • International Chemical Safety Cards (WHO/IPCS/ILO): Allyl chloride.
    • EPA Air Toxics Website: Allylchloride. U.S. Environmental Protection Agency Technology Transfer Network.
    • De Rooij, B.M., Boogaard, P.J., Commandeur, J.N., van Sittert, N.J. and Vermeulen, N.P.: Allylmercapturic acid as urinary biomarker of human exposure to Allyl chloride. Occup. Environ. Med. 54(9): 653-661, 1997.
    • He, F.S. and Zhang, S.L.: Effects of Allyl chloride on occupationally exposed subjects. Scand. J. Work Environ. Health 11(Suppl. 4): 43-45, 1985.
    • Kaye, C.M.: Biosynthesis of mercapturic acids from allyl alcohol, allyl esters and acrolein. Biochem. J. 134(4): 1093-1101, 1973.
    • Pohanish, R.P. (editor): Allyl chloride. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 97-100.
    • Wang, Q.-S., Song, F., Zhao, X., Hou, L.-Y. and Xie, K.-Q.: Expression changes of apoptic-related proteins in nerve tissues of rats treated with Allyl chloride. Toxicology 231(1): 58-67, 2007.

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Charcoal Tube (100/50 mg sections, 20/40 mesh)
  • analytical solvent: Benzene
  • alternate analytical solvent: (99:1) Carbon Disulfide/Dimethylformamide
  • maximum volume: 100 Liters
  • minimum volume: 16 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: Gas Chromatography; GC/FID
  • method reference: NIOSH Analytical Method (NIOSH 1000 (PDF))
  • method classification: Fully Validated

** All Trademarks are the property of their respective owners.

Search Chemical Sampling Information

Index

By Name

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

By CAS Number
collage image - OSHA Salt Lake Technical Center

*Accessibility Assistance: Contact OSHA's Directorate of Technical Support and Emergency Management at (202) 693-2300 for assistance accessing PDF materials.

All other documents, that are not PDF materials or formatted for the web, are available as Microsoft Office® formats and videos and are noted accordingly. If additional assistance is needed with reading, reviewing or accessing these documents or any figures and illustrations, please also contact OSHA's Directorate of Technical Support and Emergency Management at (202) 693-2300.

**eBooks - EPUB is the most common format for e-Books. If you use a Sony Reader, a Nook, or an iPad you can download the EPUB file format. If you use a Kindle, you can download the MOBI file format.

Back to Top

Thank You for Visiting Our Website

You are exiting the Department of Labor's Web server.

The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Users must request such authorization from the sponsor of the linked Web site. Thank you for visiting our site. Please click the button below to continue.

Close