- Synonyms: AA; Allylic alcohol; Propenol; 1-Propen-3-ol; 2-Propen-1-ol; 2-Propenol; Vinyl carbinol
- OSHA IMIS Code Number: 0130
- Chemical Abstracts Service (CAS) Registry Number: 107-18-6
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: BA5075000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 1098 131
- NIOSH Pocket Guide to Chemical Hazards, Allyl alcohol: chemical description, physical properties, potentially hazardous incompatibilities, and more
- OSHA Permissible Exposure Limit (PEL):
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.5 ppm (1.19 mg/m3) TWA; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 2 ppm (5 mg/m3) TWA; 4 ppm, 10 mg/m3 STEL; Skin
- NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 20 ppm
- Potential Symptoms: Irritation of eyes, skin, upper respiratory system; headache; nausea, vomiting; lacrimation, eye redness, pain, burns, blurred vision, sensitivity to light; temporary loss of vision; skin pain, blisters; pulmonary edema; Ingestion acute: Abdominal pain, unconsciousness
- Health Effects: Acute Toxicity---short-term high hazard effects (HE4) Irritation-Eye, Nose, Throat, Bronchi, Skin---Marked (HE14) Mutagen (HE2)
- Affected Organs: Eyes, skin, respiratory system
- Vapor/air mixtures of allyl alcohol may be explosive above 21°C.
- EPA’s oral reference dose (daily oral exposure likely to be without an appreciable risk of noncancer effects during a lifetime) for allyl alcohol is 0.005 mg/kg/day.
- The concentration of allyl alcohol necessary to depress respiratory rate of mice by 50% (a measure of sensory irritation) was reported to be 3.9 ppm.
- Allyl alcohol is used for producing animal models of liver damage, which is thought to occur via metabolic activation to acrolein.
- A man who died of acute cardiotoxicity less than 2 hours after ingesting allyl alcohol had blood concentrations of allyl alcohol and acrolein of 309 and 7.2 mg/L, respectively.
- In studies with rats and mice, urinary concentrations of the metabolite, 3-hydroxypropyl mercapturic acid, increased linearly with dose of allyl alcohol, given by oral gavage.
- Date Last Revised: 06/21/2007
- Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Allyl alcohol.
- International Chemical Safety Cards (WHO/IPCS/ILO): Allyl alcohol.
- U.S. EPA Integrated Risk Information System: Allyl alcohol (CASRN 107-18-6).
- Irwin, R.D.: NTP Technical Report on the comparative toxicity studies of allyl acetate (CAS No. 591-87-7), allyl alcohol (CAS No. 107-18-6) and acrolein (CAS No. 107-02-8) administered by gavage to F344/N rats and B6C3F1 mice. Toxic. Rep. Ser. (48): 1-73, A1-H10, 2006.
- Jaeschke, H., Kleinwaechter, C. and Wendel, A.: The role of acrolein in allyl alcohol-induced lipid peroxidation and liver cell damage in mice. Biochem. Pharmacol. 36(1): 51-57, 1987.
- Nielsen, G.D., Bakbo, J.C. and Holst, E.: Sensory irritation and pulmonary irritation by airborne, allyl acetate, allyl alcohol, and allyl ether compared to acrolein. Acta Pharmacol. Toxicol. (Copenh.) 54(4): 292-298, 1984.
- Pohanish, R.P. (editor): Allyl Alcohol. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 92-94.
- Toennes, S.W., Schmidt, K., Fandiño, A.S. and Kauert, G.F.: A fatal human intoxication with herbicide allyl alcohol (2-propen-1-ol). J. Anal. Toxicol. 26(1): 55-57, 2002.
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Charcoal Tube (100/50 mg sections, 20/40 mesh)
- analytical solvent: (95:5) Carbon Disulfide:Isopropanol
- maximum volume: 10 Liters
- maximum flow rate: 0.2 L/min (TWA)
- maximum volume: 3 Liters
- maximum flow rate: 0.2 L/min (STEL)
- current analytical method: Gas Chromatography; GC/FID
- method reference: NIOSH Analytical Method (NIOSH 1402)
- method classification: Partially Validated
Wipe Sampling Method:
- Charcoal pad
- Seal pad in glass vial for shipment. Call SLTC for sampling media.
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