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Allyl alcohol

General Description

  • Synonyms: AA; Allylic alcohol; Propenol; 1-Propen-3-ol; 2-Propen-1-ol; 2-Propenol; Vinyl carbinol
  • OSHA IMIS Code Number: 0130
  • Chemical Abstracts Service (CAS) Registry Number: 107-18-6
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: BA5075000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 1098 131
  • NIOSH Pocket Guide to Chemical Hazards, Allyl alcohol: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.5 ppm (1.19 mg/m3) TWA; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 2 ppm (5 mg/m3) TWA; 4 ppm, 10 mg/m3 STEL; Skin

Health Factors

  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 20 ppm
  • Potential Symptoms: Irritation of eyes, skin, upper respiratory system; headache; nausea, vomiting; lacrimation, eye redness, pain, burns, blurred vision, sensitivity to light; temporary loss of vision; skin pain, blisters; pulmonary edema; Ingestion acute: Abdominal pain, unconsciousness
  • Health Effects: Acute Toxicity---short-term high hazard effects (HE4) Irritation-Eye, Nose, Throat, Bronchi, Skin---Marked (HE14) Mutagen (HE2)
  • Affected Organs: Eyes, skin, respiratory system
  • Notes:
    1. Vapor/air mixtures of allyl alcohol may be explosive above 21°C.
    2. EPA’s oral reference dose (daily oral exposure likely to be without an appreciable risk of noncancer effects during a lifetime) for allyl alcohol is 0.005 mg/kg/day.
    3. The concentration of allyl alcohol necessary to depress respiratory rate of mice by 50% (a measure of sensory irritation) was reported to be 3.9 ppm.
    4. Allyl alcohol is used for producing animal models of liver damage, which is thought to occur via metabolic activation to acrolein.
    5. A man who died of acute cardiotoxicity less than 2 hours after ingesting allyl alcohol had blood concentrations of allyl alcohol and acrolein of 309 and 7.2 mg/L, respectively.
    6. In studies with rats and mice, urinary concentrations of the metabolite, 3-hydroxypropyl mercapturic acid, increased linearly with dose of allyl alcohol, given by oral gavage.
  • Date Last Revised: 06/21/2007
  • Literature Basis:
    • NIOSH Pocket Guide to Chemical Hazards: Allyl alcohol.
    • International Chemical Safety Cards (WHO/IPCS/ILO): Allyl alcohol.
    • U.S. EPA Integrated Risk Information System: Allyl alcohol (CASRN 107-18-6).
    • Irwin, R.D.: NTP Technical Report on the comparative toxicity studies of allyl acetate (CAS No. 591-87-7), allyl alcohol (CAS No. 107-18-6) and acrolein (CAS No. 107-02-8) administered by gavage to F344/N rats and B6C3F1 mice. Toxic. Rep. Ser. (48): 1-73, A1-H10, 2006.
    • Jaeschke, H., Kleinwaechter, C. and Wendel, A.: The role of acrolein in allyl alcohol-induced lipid peroxidation and liver cell damage in mice. Biochem. Pharmacol. 36(1): 51-57, 1987.
    • Nielsen, G.D., Bakbo, J.C. and Holst, E.: Sensory irritation and pulmonary irritation by airborne, allyl acetate, allyl alcohol, and allyl ether compared to acrolein. Acta Pharmacol. Toxicol. (Copenh.) 54(4): 292-298, 1984.
    • Pohanish, R.P. (editor): Allyl Alcohol. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 92-94.
    • Toennes, S.W., Schmidt, K., Fandiño, A.S. and Kauert, G.F.: A fatal human intoxication with herbicide allyl alcohol (2-propen-1-ol). J. Anal. Toxicol. 26(1): 55-57, 2002.

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Charcoal Tube (100/50 mg sections, 20/40 mesh)
  • analytical solvent: (95:5) Carbon Disulfide:Isopropanol
  • maximum volume: 10 Liters
  • maximum flow rate: 0.2 L/min (TWA)
  • maximum volume: 3 Liters
  • maximum flow rate: 0.2 L/min (STEL)
  • current analytical method: Gas Chromatography; GC/FID
  • method reference: NIOSH Analytical Method (NIOSH 1402)
  • method classification: Partially Validated
Wipe Sampling Method:
  • Charcoal pad
  • Seal pad in glass vial for shipment. Call SLTC for sampling media.

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