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General Description

  • Synonyms: 1,4-Dicyanobutane; Hexanedinitrile; Tetramethylene cyanide
  • OSHA IMIS Code Number: A509
  • Chemical Abstracts Service (CAS) Registry Number: 111-69-3
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AV2625000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2205 153
  • NIOSH Pocket Guide to Chemical Hazards, Adiponitrile: chemical description, physical properties, potentially hazardous incompatibilities, and more.

Exposure Limits

  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 2 ppm, 9 mg/m3 TWA; Skin
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 4 ppm, 18 mg/m3 TWA

Health Factors

  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): Not determined
  • Potential Symptoms: CNS Disturbances (HE7); Irritation-Eyes, Skin; Asphyxiant (HE17); LC50 (4-hr inhalation, rat) 386 ppm; LD50 (oral, rabbit) 22 mg/kg
  • Health Effects: Irritation-Eyes, Nose, Throat, Skin---Marked (HE14); Respiratory effects---pulmonary edema (HE11)
  • Affected organs: CNS, respiratory system, cardiovascular system; eyes; skin
  • Note: Metabolized in the body to cyanide.
  • Date Last Revised: 02/25/2003
  • Literature Basis:
    • (symptoms) Ramaiah, S.K. and Mehendale, H.M. Adiponitrile, in Enclyclopedia of Toxicology, Vol. 1, Wexler, P., ed. San Diego: Academic Press, 1998, pp. 28-30.
    • (health effects and target organs) NIOSH Guide to Chemical Hazards, Adiponitrile
    • (rat inhalational toxicology) Smith, L.W. and Kennedy, G.L., Jr. Inhalation toxicity of adiponitrile in rats. Toxicol. Appl. Pharmacol. 65: 257-263, 1982.

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • Charcoal Tube (100/50 mg sections)
  • analytical solvent: Chloroform
  • maximum volume: 10 Liters
  • maximum flow rate: 0.1 L/min
  • current analytical method: Gas Chromatography; GC/FID
  • method reference: OSHA SLTC In-House File
  • method classification: Not Validated

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