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Chemical Sampling Information (CSI)
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General Description

Synonyms: 1,4-Dicyanobutane; Hexanedinitrile; Tetramethylene cyanide

OSHA IMIS Code Number: A509

Chemical Abstracts Service (CAS) Registry Number: 111-69-3

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AV2625000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2205 153

NIOSH Pocket Guide to Chemical Hazards, Adiponitrile: chemical description, physical properties, potentially hazardous incompatibilities, and more.

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 2 ppm, 9 mg/m3 TWA; Skin

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 4 ppm, 18 mg/m3 TWA

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): Not determined

Potential Symptoms: CNS Disturbances (HE7); Irritation-Eyes, Skin; Asphyxiant (HE17); LC50 (4-hr inhalation, rat) 386 ppm; LD50 (oral, rabbit) 22 mg/kg

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Marked (HE14); Respiratory effects---pulmonary edema (HE11)

Affected organs: CNS, respiratory system, cardiovascular system; eyes; skin

Note: Metabolized in the body to cyanide.

Date Last Revised: 02/25/2003

Literature Basis:

  • (symptoms)
    Ramaiah, S.K. and Mehendale, H.M. Adiponitrile, in Enclyclopedia of Toxicology, Vol. 1, Wexler, P., ed. San Diego: Academic Press, 1998, pp. 28-30.
  • (health effects and target organs)
    NIOSH Guide to Chemical Hazards, Adiponitrile
  • (rat inhalational toxicology)
    Smith, L.W. and Kennedy, G.L., Jr. Inhalation toxicity of adiponitrile in rats. Toxicol. Appl. Pharmacol. 65: 257-263, 1982.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:

  • sampling media: Charcoal Tube (100/50 mg sections)
    analytical solvent: Chloroform
    maximum volume: 10 Liters
    maximum flow rate: 0.1 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA SLTC In-House File
    method classification: Not Validated

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