US Dept of Labor

Occupational Safety & Health AdministrationWe Can Help

Adiponitrile

General Description

  • Synonyms: 1,4-Dicyanobutane; Hexanedinitrile; Tetramethylene cyanide
  • OSHA IMIS Code Number: A509
  • Chemical Abstracts Service (CAS) Registry Number: 111-69-3
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AV2625000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2205 153
  • NIOSH Pocket Guide to Chemical Hazards, Adiponitrile: chemical description, physical properties, potentially hazardous incompatibilities, and more.

Exposure Limits

  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 2 ppm, 9 mg/m3 TWA; Skin
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 4 ppm, 18 mg/m3 TWA

Health Factors

  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): Not determined
  • Potential Symptoms: CNS Disturbances (HE7); Irritation-Eyes, Skin; Asphyxiant (HE17); LC50 (4-hr inhalation, rat) 386 ppm; LD50 (oral, rabbit) 22 mg/kg
  • Health Effects: Irritation-Eyes, Nose, Throat, Skin---Marked (HE14); Respiratory effects---pulmonary edema (HE11)
  • Affected organs: CNS, respiratory system, cardiovascular system; eyes; skin
  • Note: Metabolized in the body to cyanide.
  • Date Last Revised: 02/25/2003
  • Literature Basis:
    • (symptoms) Ramaiah, S.K. and Mehendale, H.M. Adiponitrile, in Enclyclopedia of Toxicology, Vol. 1, Wexler, P., ed. San Diego: Academic Press, 1998, pp. 28-30.
    • (health effects and target organs) NIOSH Guide to Chemical Hazards, Adiponitrile
    • (rat inhalational toxicology) Smith, L.W. and Kennedy, G.L., Jr. Inhalation toxicity of adiponitrile in rats. Toxicol. Appl. Pharmacol. 65: 257-263, 1982.

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • Charcoal Tube (100/50 mg sections)
  • analytical solvent: Chloroform
  • maximum volume: 10 Liters
  • maximum flow rate: 0.1 L/min
  • current analytical method: Gas Chromatography; GC/FID
  • method reference: OSHA SLTC In-House File
  • method classification: Not Validated

** All Trademarks are the property of their respective owners.

Search Chemical Sampling Information

Index

By Name

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

By CAS Number
collage image - OSHA Salt Lake Technical Center
Back to Top

Thank You for Visiting Our Website

You are exiting the Department of Labor's Web server.

The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Users must request such authorization from the sponsor of the linked Web site. Thank you for visiting our site. Please click the button below to continue.

Close