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Chemical Sampling Information (CSI)
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General Description

Synonyms: Acifloctin; Acinetten; Adilatetten; Adipinic Acid; 1,4-Butanedicarboxylic Acid; 1,6-Hexanedioic Acid

OSHA IMIS Code Number: A155

Chemical Abstracts Service (CAS) Registry Number: 124-04-9

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AU8400000

Chemical Description and Physical Properties:
    freely soluble in methanol, ethanol; soluble in acetone
    molecular formula: C6H10O4
    molecular weight: 146.16
    boiling point: 338°C
    vapor pressure: Pa at 18.5°C: 10
    melting point: 152°C
    density: 1.36 g/ml
Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3

Health Factors

Potential Symptoms: Irritation eyes, respiratory system; cough, sore throat, asthma; contact dermatitis

Health Effects: Irritation-Eyes, Nose, Throat---Mild (HE16); Respiratory effects---asthma (HE9)

Affected Organs: Eyes, skin, respiratory system

Notes:
  1. There is no OSHA PEL for adipic acid. It is on FDA's list of food additives that are "Generally Recognized as Safe" (21CFR 184.1009).
  2. A single intratracheal instillation in rats caused persistent lung alterations, including pulmonary fibrosis (Kennedy, 2002).
Date Last Revised: 01/15/2004

Literature Basis:
  • International Chemical Safety Cards (WHO/IPCS/ILO) Adipic acid.
  • Kennedy, G.L., Jr. Toxicity of adipic acid. Drug Chem. Toxicol. 25(2): 191-202, 2002.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • sampling media: OSHA Versatile Sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg sections, 20/60 mesh) with a Glass Fiber Filter enclosed
    analytical solvent: Methanol
    maximum volume: 100 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA SLTC In-House File
    method classification: Not Validated
    analytical conditions: Column: 15 m x 0.32 mm ID Stabilwax 1 micron film Temp: Oven 200 - 210° deg C; Inj 220° deg C; Det 220° deg C

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