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Adipic Acid

General Description

  • Synonyms: Acifloctin; Acinetten; Adilatetten; Adipinic Acid; 1,4-Butanedicarboxylic Acid; 1,6-Hexanedioic Acid
  • OSHA IMIS Code Number: A155
  • Chemical Abstracts Service (CAS) Registry Number: 124-04-9
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AU8400000
  • Chemical Description and Physical Properties:
    • freely soluble in methanol, ethanol; soluble in acetone
    • molecular formula: C6H10O4
    • molecular weight: 146.16
    • boiling point: 338°C
    • vapor pressure: Pa at 18.5°C: 10
    • melting point: 152°C
    • density: 1.36 g/ml

Exposure Limits

  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3

Health Factors

  • Potential Symptoms: Irritation eyes, respiratory system; cough, sore throat, asthma; contact dermatitis
  • Health Effects: Irritation-Eyes, Nose, Throat---Mild (HE16); Respiratory effects---asthma (HE9)
  • Affected Organs: Eyes, skin, respiratory system
  • Notes:
    1. There is no OSHA PEL for adipic acid. It is on FDA's list of food additives that are "Generally Recognized as Safe" (21CFR 184.1009).
    2. A single intratracheal instillation in rats caused persistent lung alterations, including pulmonary fibrosis (Kennedy, 2002).
  • Date Last Revised: 01/15/2004
  • Literature Basis:
    • International Chemical Safety Cards (WHO/IPCS/ILO) Adipic acid.
    • Kennedy, G.L., Jr. Toxicity of adipic acid. Drug Chem. Toxicol. 25(2): 191-202, 2002.

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • OSHA Versatile Sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg sections, 20/60 mesh) with a Glass Fiber Filter enclosed
  • analytical solvent: Methanol
  • maximum volume: 100 Liters
  • maximum flow rate: 0.2 L/min
  • current analytical method: Gas Chromatography; GC/FID
  • method reference: OSHA SLTC In-House File
  • method classification: Not Validated
Conditions:

Column: 15 m x 0.32 mm ID Stabilwax 1 micron film Temp: Oven 200 - 210° deg C; Inj 220° deg C; Det 220° deg C

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