Affected organs: Cardiovascular system, liver, CNS, skin, lung and bowel; blood, respiratory system, and eyes
Note: Partially metabolized to cyanide by cytochrome P450-2E1.
(low grade anemia, leukocytosis, kidney irritation, and mild jaundice) Cohrssen, B.: Cyanides and nitriles (Chapter 61). In Patty's Toxicology, 5th Ed., Vol. 4, Bingham, E., Cohrssen, B., and Powell, C.H., eds. New York: John Wiley & Sons, Inc., pp. 1400-1404, 2001.
(dyspnea, burning sensation in the throat, impaired judgement, death.) Mangipudy, R.S., and Mehendale, M.H. Acrylonitrile. In Encyclopedia of Toxicology, Vol. 1, Wexler, P. ed. New York: Academic Press, pp. 27-28, 1998.
(convulsion and hysterical) Sitting, M.: Acrylonitrile. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 3rd Ed. Vol. 1, pp. 52-54, 1991.
(metabolism) Their, R., Balkenhol, H., Lewalter, J., Selinski, S., Dommermuth, A. and Bolt, H.M. Influence of polymorphisms of the human glutathione transferases and cytochrome P450 2E1 enzyme on the metabolism and toxicity of ethylene oxide and acrylonitrile. Mutation Res. 482(1-2): 41-46, 2001.
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