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Acrylamide

General Description

  • Synonyms: Propenamide; Acrylamide monomer; Acrylic amide
  • OSHA IMIS Code Number: 0115
  • Chemical Abstracts Service (CAS) Registry Number: 79-06-1
  • NIOSH Registry of Toxic Effects (RTECS) Identification Number: AS3325000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2074 153P
  • NIOSH Pocket Guide to Chemical Hazards, Acrylamide: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.03 mg/m3 TWA; Skin; Appendix A3 (Confirmed Animal Carcinogen with Unknown Relevance to Humans)
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.03 mg/m3 TWA; Skin; Appendix A - Potential Occupational Carcinogen

Health Factors

  • International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, possibly carcinogenic to humans
  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 60 mg/m3
  • Potential Symptoms: Ataxia, tremor; numb limbs, paresthesia; decreased reflexes; speech disturbances; drowsiness, fatigue, lethargy; memory loss; weakness; weight loss; eye, skin irritation; red or blue discoloration, peeling and sloughing of skin in the hands.
  • Health Effects: Polyneuropathy (HE7); Eyes, Skin Irritation, Dermatitis (HE14); Mutagen/Suspect carcinogen (HE2); LD50 (oral, rat) 170 mg/kg
  • Affected Organs: CNS, PNS, skin, eyes.
  • Date Last Revised: 08/17/2001
  • Literature Basis:
    • (sensory disturbances in the hands and feet) Bleecker, M.L.: Toxic peripheral neuropathy. In: Environmental & Occupational Medicine, 3rd Ed., W.N.Rom, ed. New York: Lippincott-Raven Publishers, pp.697-707, 699, 1998.
    • (red or blue discoloration of skin) Cloeren, M.: Acrylamide. In: Hazardous Materials Toxicology, Sullivan, J.B. and Krieger, G.R. eds. Baltimore: Williams & Wilkens, pp. 940-945, 1992.
    • (decreased reflexes) Parod, R.: Acrylamide. In: Encyclopedia of Toxicology, Vol. 1, Waxler, P., ed. New York: Academic Press, pp. 25-26, 1998.
    • (peeling, redness on hands and feet; teratogenicity, weight loss) Sanchez, M.R.: Dermatologic principles. In: Goldfrank's Toxicology Emergencies, 6th Ed., Goldfrank, L.R., Flomenbaum, N.E., LewIn: N.A., Weisman, R.S., Howland, M.A., Hoffman, R.S. eds. Connecticut: Appleton & Lange, pp. 474-499, 1998.
    • (drowsiness, paresthesia, tremor, speech disturbances) Sitting, M.: Acrylamide. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 3rd Ed., Vol. 1, pp. 49-51, 1991.

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • 13 mm Glass Fiber Filter in Swinnex (TM) Cassette in series with Silica Gel Tube (150/75 mg sections)
  • analytical solvent: Methanol
  • maximum volume: 120 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: Gas Chromatography; GC/NPD
  • method reference: OSHA Manual of Analytical Methods (OSHA 21)
  • method classification: Fully Validated
  • note: Glass fiber filter and gaskets are extracted in 1 mL of methanol as soon as possible after sampling.
  • OSHA Versatile Sampler (OVS-7) - 13 mm XAD-7 tube (270/140 mg sections) with Glass Fiber Filter enclosed
  • analytical solvent: (95:5) Water/Methanol
  • maximum volume: 120 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/UV
  • method reference: OSHA Manual of Analytical Methods (OSHA PV2004)
  • method classification: Fully Validated

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