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Chemical Sampling Information (CSI)
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General Description

Synonyms: Propenamide; Acrylamide monomer; Acrylic amide

OSHA IMIS Code Number: 0115

Chemical Abstracts Service (CAS) Registry Number: 79-06-1

NIOSH Registry of Toxic Effects (RTECS) Identification Number: AS3325000

Department of Transportation Regulation Number (49 CFR 172.101): 2074 153P

NIOSH Pocket Guide to Chemical Hazards, Acrylamide: chemical description, physical properties, potentially hazardous incompatibilities, and more


Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 0.3 mg/m3 TWA; Skin

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 0.3 mg/m3 TWA; Skin

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.03 mg/m3 TWA; Skin; Appendix A3 (Confirmed Animal Carcinogen with Unknown Relevance to Humans)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.03 mg/m3 TWA; Skin; Appendix A - Potential Occupational Carcinogen

Health Factors

International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, possibly carcinogenic to humans

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 60 mg/m3

Potential Symptoms: Ataxia, tremor; numb limbs, paresthesia; decreased reflexes; speech disturbances; drowsiness, fatigue, lethargy; memory loss; weakness; weight loss; eye, skin irritation; red or blue discoloration, peeling and sloughing of skin in the hands.

Health Effects: Polyneuropathy (HE7); Eyes, Skin Irritation, Dermatitis (HE14); Mutagen/Suspect carcinogen (HE2); LD50 (oral, rat) 170 mg/kg

Affected Organs: CNS, PNS, skin, eyes.

Date Last Revised: 08/17/2001

Literature Basis:

  • (sensory disturbances in the hands and feet)
    Bleecker, M.L.: Toxic peripheral neuropathy. In: Environmental & Occupational Medicine, 3rd Ed., W.N.Rom, ed. New York: Lippincott-Raven Publishers, pp.697-707, 699, 1998.
  • (red or blue discoloration of skin)
    Cloeren, M.: Acrylamide. In: Hazardous Materials Toxicology, Sullivan, J.B. and Krieger, G.R. eds. Baltimore: Williams & Wilkens, pp. 940-945, 1992.
  • (decreased reflexes)
    Parod, R.: Acrylamide. In: Encyclopedia of Toxicology, Vol. 1, Waxler, P., ed. New York: Academic Press, pp. 25-26, 1998.
  • (peeling, redness on hands and feet; teratogenicity, weight loss)
    Sanchez, M.R.: Dermatologic principles. In: Goldfrank's Toxicology Emergencies, 6th Ed., Goldfrank, L.R., Flomenbaum, N.E., LewIn: N.A., Weisman, R.S., Howland, M.A., Hoffman, R.S. eds. Connecticut: Appleton & Lange, pp. 474-499, 1998.
  • (drowsiness, paresthesia, tremor, speech disturbances)
    Sitting, M.: Acrylamide. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 3rd Ed., Vol. 1, pp. 49-51, 1991.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:

  • sampling media: 13 mm Glass Fiber Filter in Swinnex (TM) Cassette in series with Silica Gel Tube (150/75 mg sections)
    analytical solvent: Methanol
    maximum volume: 120 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: Gas Chromatography; GC/NPD
    method reference: OSHA Manual of Analytical Methods (OSHA 21)
    method classification: Fully Validated
    note: Glass fiber filter and gaskets are extracted in 1 mL of methanol as soon as possible after sampling.
  • sampling media: OSHA Versatile Sampler (OVS-7) - 13 mm XAD-7 tube (270/140 mg sections) with Glass Fiber Filter enclosed
    analytical solvent: (95:5) Water/Methanol
    maximum volume: 120 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: OSHA Manual of Analytical Methods (OSHA PV2004)
    method classification: Fully Validated

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