- Synonyms: symmetrical Tetrabromoethane; 1,1,2,2-Tetrabromoethane
- OSHA IMIS Code Number: 0080
- Chemical Abstracts Service (CAS) Registry Number: 79-27-6
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KI8225000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2504 159
- NIOSH Pocket Guide to Chemical Hazards, Acetylene Tetrabromide: chemical description, physical properties, potentially hazardous incompatibilities, and more
- OSHA Permissible Exposure Limit (PEL):
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1 ppm, 14 mg/m3 TWA
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Appendix D - Substances With No Established RELs
- NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 8 ppm
- Potential Symptoms: Eye, skin and respiratory tract irritation; anorexia, nausea; severe headache; abdominal pain; heartburn, dizziness, CNS depression; jaundice, urobilinuria, bilirubinuria; monocytosis.
- Health Effects: Cumulative liver and kidney damage (HE3); Cumulative lung damage (HE10); Central nervous system effects (HE7, HE8); Dermatitis; LD50 (oral, rabbit, guinea pig) 400 mg/kg. SKIN ABS.
- Affected Organs: Eyes, upper respiratory system, liver, kidney; skin, and brain.
- Involved in a case report of solvent-induced encephalopathy in a worker after acute exposure.
- Induced stomach tumors in mice by repeated skin application.
- (urobilinuria, bilirubinuria, liver irritation, kidney damage...) Reid, J.B.: Saturated methyl halogenated aliphatic hydrocarbons (Chapter 62). In: Patty's Toxicology, 5th Ed., Vol. 5, Bingham, E., Cohrssen, B., Powell, C.H. eds. New York: John Wiley & Sons, Inc., pp. 185-189, 2001.
- (encephalopathy) Morrow, L.A., Callender, T., Lottenberg, S., Buchsbaum, M.S., Hodgson, M.J., and Robin, N.: PET and neurobehavioral evidence of tetrabromoethane encephalopathy. J. Neuropsychiatry Clin. Neurosci. 2(4) : 431-435, 1990.
- (stomach tumors in mice) Van Duuren, B.L., Goldschmidt, B.M., Loewengart, G., Smith, A.C., Melchionne, S., Seldman, I. and Roth, D.: Carcinogenicity of halogenated olefinic and aliphatic hydrocarbons in mice. J. Natl. Cancer Inst. 63(6): 1433-1439, 1979.
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Silica Gel Tube (150/75 mg sections)
- analytical solvent: Tetrahydrofuran
- sampling time: 100 Liters
- maximum flow rate: 1.0 L/min
- current analytical method: Gas Chromatography; GC/FID
- method reference: NIOSH Manual of Analytical Methods (NIOSH 2003 (PDF)).
- method classification: Fully Validated
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