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2-Acetylaminofluorene

General Description

  • Synonyms: N-(2-Fluorenyl)acetamide; 2-AAF; 2-Acetaminofluorene
  • OSHA IMIS Code Number: 0065
  • Chemical Abstracts Service (CAS) Registry Number: 53-96-3
  • NIOSH Registry of Toxic Effects (RTECS) Identification Number: AB9450000; 839
  • Chemical Description and Physical Properties:
    • solid; soluble in alcohols and glycols; insoluble in water
    • molecular weight: 223
    • melting point: 194°C

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 29 CFR 1910.1014, Potential Carcinogen

Health Factors

  • Carcinogenic Classification:
    • National Toxicology Program (NTP): Suspect Human Carcinogen
  • Potential Symptoms: Reduced functioning of liver, kidneys, bladder, pancreas (carcinogenic)
  • Health Effects: Cancer - Currently regulated by OSHA as a carcinogen; chiefly work practice standards (HE1) LD50 (oral,mouse) 1020 mg/kg
  • Affected Organs: Liver, bladder, kidney, pancreas, skin, lungs

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Glass Fiber Filter (37 mm)
  • analytical solvent: Acetonitrile
  • maximum volume: 250 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/UV
  • method reference: 2 (OSHA In-House File)
  • method classification: Not Validated
Wipe Sampling Method:
  • Glass Fiber Filter
Bulk Method:
  • Limit the amount of bulk submitted to one gram or one mL
Conditions:

Acetonitrile extraction; C18 column; UV det: 280, 313; 0.6 mL/min; 75% methanol 25% water; retention time, 11.3 min; DL 0.8 ng/inj; C/P DB 3/83

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