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Acetophenone

General Description

  • Synonyms: alpha-Acetophenone; Acetylbenzene; 1-Phenylethanone; Phenyl methyl ketone
  • OSHA IMIS Code Number: A169
  • Chemical Abstracts Service (CAS) Registry Number: 98-86-2
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AM5250000
  • Chemical Description and Physical Properties:
    • colorless liquid or white crystals, with characteristic odor
    • molecular formula: C8H8O
    • molecular weight: 120.15
    • boiling point: 202°C
    • vapor pressure: 0.133 kPa @ 15°C
    • melting point: 20°C

Exposure Limits

  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 10 ppm, 49 mg/m3 TWA

Health Factors

  • Potential Symptoms: Eye irritation; headache, dizziness, drowsiness, unconsciousness; dry skin, burning sensation, rash; Ingestion Acute: Nausea; Skin Absorption
  • Health Effects: Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15); Narcosis (HE8)
  • Affected Organs: Eyes, skin, CNS
  • Notes:
    1. OSHA does not have a PEL for acetophenone.
    2. Acetophenone is permitted by the FDA for direct addition to food as a flavoring substance or adjuvant (21 CFR 172.515).
    3. EPA's oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) is 0.4 mg/kg/day.
    4. Acetophenone has not been tested for carcinogenicity, teratogenicity, or for reproductive toxicity.
    5. Early in the 20th century, acetophenone was sold as the sedative-hypnotic drug, Hypnon (1-oz. vial, $1.20).
  • Date Last Revised: 02/11/2005
  • Literature Basis:
    • International Chemical Safety Cards (WHO/IPCS/ILO): Acetophenone.
    • U.S. EPA Integrated Risk Information System: Acetophenone (CASRN 98-86-2).
    • Eberde, E.G. (editor) Drugs and chemicals general price list. The Southern Pharmaceutical Journal 5(4): 1-7, 1912.
    • Pohanish, R.P. (editor) Acetophenone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 44-45.

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • Tenax GC Tube (30/15 mg sections)
  • analytical solvent: (95:5) Carbon Disulfide: Isopropanol
  • maximum volume: 12 Liters
  • maximum flow rate: 0.1 L/min
  • current analytical method: Gas Chromatography; GC/FID
  • method reference: OSHA Analytical Method (OSHA PV2003)
  • method classification: Partially Validated

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