- Synonyms: Ethanoic anhydride; Acetic acid anhydride; Acetyl oxide
- OSHA IMIS Code Number: 0030
- Chemical Abstracts Service (CAS) Registry Number: 108-24-7
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AK1925000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 1715 137
- NIOSH Pocket Guide to Chemical Hazards, Acetic Anhydride: chemical description, physical properties, potentially hazardous incompatibilities, and more
- OSHA Permissible Exposure Limit (PEL):
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 15 ppm, 21 mg/m3 TWA
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 20 mg/m3 Ceiling
- NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 200 ppm
- Potential Symptoms: Conjunctivitis, lacrimation, corneal edema, burns, opacity, photophobia; burning sensation in nose and throat; cough, dyspnea, bronchitis, pulmonary edema; skin burns, blisters, dermatitis, sensitization. Death can occur from circulatory collapse (shock), asphyxia due to glottic edema or from damage to respiratory system.
- Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Acute Cardiorespiratory Toxicity (HE4); LD50 (oral, rat) 1780 mg/kg
- Affected Organs: Respiratory system, eyes, skin
- Notes: Eyes affected by ≥0.36mg/m3
Date Last Revised: 10/16/2001
- (eyes affected by 0.36mg/ m3) Wagner, F.S., Jr.: Acetic anhydride. In: Kirk-Othmer Encyclopedia of Chemical Technology, 4th Ed., Vol. 1. New York: John Wiley and Sons, pp.142-154, 1991.
- (death from inhalation) Sinclair, J.S., McManus, D.T., O'Hara, M.D. and Millar, R.: Fatal inhalation injury following an industrial accident involving acetic anhydride. Burns 20(5): 469-470, 1994.
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Two Coated Glass Fiber Filters (37 mm) Coating is 10 mg Veratryamine and 10 mg di-n-octylphthalate.
- analytical solvent: (50:50) Isopropanol:Toluene
- maximum volume: 7.5 Liters
- maximum flow rate: 0.05 L/min
- current analytical method: Gas Chromatography; GC/NPD
- method reference: OSHA Analytical Method (OSHA 102)
- method classification: Fully Validated
- note: Store filters under refrigeration and use within 1 month. Small interfering peaks start appearing after that time.
On-Site Sampling Technique/Method:
- Detector Tube
- manufacturer: Gastec
- model type: Acetic Acid Tube 81
- sampling information: 1 stroke
- upper measuremnet limit: 15 ppm
- detection limit: approximately 0.3 ppm
- overall uncertainty: 16.4%
- method reference: on-site air secondary (manufacturer)
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