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Synonyms: Abietinic Acid; Sylvic Acid; Rosin Core Solder Pyrolysis Products
OSHA IMIS Code Number: A616
Chemical Abstracts Service (CAS) Registry Number: 514-10-3
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: TP8580000
Chemical Description and Physical Properties:
yellow-orange crystalline powder
molecular weight: 302.50
molecular formula: C20H30O2
melting point: 172-175°C
flash point: 187°C
Potential Symptoms: Irritation of eyes, nose, and respiratory system; lacrimation; cough, chest tightness; nausea, vomiting; erythematovesicular dermatitis
Health Effects: Irritation – Eye, Nose, Throat---Marked (HE14); Asthma (HE9); Allergic contact dermatitis (HE3)
Affected Organs: Skin, respiratory system
Date Last Revised: 10/20/2006
- Abietic acid is a component of rosin from conifer (pine, fir, spruce) trees and may be found in solder flux, wood dust, paper products, and some wart-removing products, among others. Its biosynthetic pathway has been elucidated.
- Skin and respiratory sensitization may be due to hydroperoxy and epoxy oxidation products of abietic acid, rather than to abietic acid itself.
- International Chemical Safety Cards (WHO/IPCS/ILO): Rosin.
- Berge, P.S., Harries, M.G., O’Brien, I. and Pepys, J.: Bronchial provocation studies in workers exposed to the fumes of electronic soldering fluxes. Clin. Allergy 10(2): 137-149, 1980.
- Estlander, T., Jolanki, R., Alanko, K. and Kanerva, L.: Occupational allergic contact dermatitis caused by wood dusts. Contact Dermatitis 44(4): 213-217, 2001.
- Funk, C. and Croteau, R.: Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis. Arch. Biochem. Biophys. 308(1): 258-266, 1994.
- Gäfvert, E., Shao, L.P., Karlberg, A.T., Nilsson, U. and Nilsson, J.L.: Contact allergy to resin acid hydroperoxides. Hapten binding via free radicals and epoxides. Chem. Res. Toxicol. 7(2): 260-266, 1994.
- Keira, T., et al.: Adverse effects of colophony. Ind. Health 35(1): 1-7, 1997.
- Sadhra, S., Foulds, I.S. and Gray, C.N.: Identification of contact allergens in unmodified rosin using a combination of patch testing and analytical chemistry techniques. Br. J. Dermatol. 134(4): 662-668, 1996.
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Glass Fiber Filter (37 mm)
analytical solvent: Methanol
maximum volume: 200 Liters
maximum flow rate: 2.0 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: (OSHA In-house File)
method classification: Not Validated
Conditions: Column: C18; Mobile Phase: 60:40:0.1 Acetonitrile: Water: Phosphoric acid; Detector Wavelength: 254nm
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