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Chemical Sampling Information (CSI)
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General Description

Synonyms: 2,4-Dimethylaniline; 2,4-Dimethylaminobenzene; Aminodimethylbenzene; 2,4-Xylidine; 2,5-Xylidine; (there are 6 isomers for Xylidine)

OSHA IMIS Code Number: 2600

Chemical Abstracts Service (CAS) Registry Number: 1300-73-8

Other Chemical Abstracts Service (CAS) Registry Numbers: 95-68-1; 95-78-3

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: ZE8575000; 88480

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: UN1711 Poison

Chemical Description and Physical Properties:

pale yellow to brown liquid with a weak, aromatic amine odor
molecular weight: 121
vapor pressure: <1 mm
boiling point: 415 to 439°F

Incompatibilities: Strong oxidizers, hypochlorite bleaches

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 5 ppm, 25 mg/m3

Construction Industry: 5 ppm, 25 mg/m3 TWA (Skin)

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.5 ppm TWA (Inhalable Fraction) (Vapor and Aerosol) (Skin); Appendix A3 (Confirmed Animal Carcinogen with Unknown Relevance to Humans) (mixed isomers); BEI

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 2 ppm TWA (Skin)

Health Factors

Carcinogenic Classification:

International Agency for Research on Cancer (IARC): Group 3, not classifiable as to its carcinogenicity to humans (2,4-Xylidine and 2,5-Xylidine)

Potential Symptoms: Anoxia, cyanosis; lung, liver, kidney damage

Health Effects: Methemoglobinemia (HE13); Acute systemic toxicity (HE4)

Affected Organs: Blood, lungs, liver, kidneys, CVS

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Silica Gel Tube (150/75 mg sections, 20/40 mesh)
    maximum volume: 30 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: 1 (NIOSH 2002 [32 KB PDF, 6 pages])
    method classification: Fully Validated

Secondary Laboratory Sampling/Analytical Method (SAM2):

  • part #: MIRAN 1A &1B
    range: 0.2 ppm @ 7.2 um

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