 |
Chemical Sampling Information |
|
| 1,1,2-Trichloro-1,2,2-Trifluoroethane |
|
General Description
Synonyms: Chlorofluorocarbon-113, CFC-113, Freon® 113, Genetron® 113, Halocarbon 113, Refrigerant 113, TTE
OSHA IMIS Code Number: 2485
Chemical Abstracts Service (CAS) Registry Number: 76-13-1
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KJ4000000
NIOSH Pocket Guide to Chemical Hazards, 1,1,2-Trichloro-1,2,2-trifluoroethane: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 1000 ppm, 7600 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 1000 ppm, 7600 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 1000 ppm, 7600 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1000 ppm, 7670 mg/m3 TWA; 1250 ppm, 9590 mg/m3 STEL; Appendix A4 - Not Classifiable as a Human Carcinogen
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1000 ppm, 7600 mg/m3 TWA, 1250 ppm, 9500 mg/m3 STEL
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 2000 ppm
Potential symptoms: Irritation of eyes, skin, throat; drowsiness; dermatitis; CNS depression; loss of consciousness; cardiac arrhythmia.
Health Effects: Acute toxicity---Sudden death (HE4); Narcosis (HE8)
Irritation-Eyes, Nose, Throat, Skin---Mild (HE16)
Affected organs: Skin, heart, CNS, cardiovascular system
Notes:
- EPA's reference dose (RfD, daily oral dose likely to be without an appreciable risk of deleterious effects during a lifetime) for 1,1,2-trichloro-1,2,2-trifluoroethane is 30 mg/kg/day.
- Pharmacokinetic studies with human volunteers who breathed 1,1,2-trichloro-1,2,2-trifluoroethane concentrations in the range of 258 to 1004 ppm for four hours indicated mean peak blood levels of 0.69, 1.2 and 3.1 μg/ml and elimination by exhalation with mean half-lives in a three-compartment model of 0.22, 2.3, and 29 hours.
- A chronic inhalation study in rats (6 hours/day, 5 days/week, 24 months) indicated a NOEL of 2000 ppm.
- Several deaths have been reported for exposure to 1,1,2-trichloro-1,2,2-trifluoroethane in occupational settings, which were thought to be due, in most cases, to cardiac arrhythmias.
Date Last Revised: 08/03/2006
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: 1,1,2-Trichloro-1,2,2-trifluoroethane
- International Chemical Safety Cards (WHO/IPCS/ILO): 1,1,2-Trichloro-1,2,2-trifluoroethane.
- U.S. EPA Integrated Risk Information System: 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) (CASRN 76-13-1).
- Clark, M.A., Jones, J.W., Robinson, J.J. and Lord, J.T.: Multiple deaths resulting from shipboard exposure to trichlorotrifluoroethane. J. Forensic Sci. 30(4): 1256-1259, 1985.
- Kaufman, J.D., Silverstein, M.A. and Moure-Eraso, R.: Atrial fibrillation and sudden death related to occupational solvent exposure. Am. J. Ind. Med. 25(5): 731-735, 1994.
- May, D.C. and Blotzer, M.J.: A report of occupational deaths attributed to fluorocarbon-113. Arch. Environ. Health 39(5): 352-354, 1984.
- McGee, M.B., Meyer, R.F. and Jejurikar, S.G.: A death resulting from trichlorotrifluoroethane poisoning. J. Forensic Sci. 35(6): 1453-1460, 1990.
- Pohanish, R.P. (editor): 1,1,2-Trichloro-1,2,2-Trifluoroethane. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2263-2265.
- Trochimowicz, H.J., Gusch, G.M., Chiu, T. and Wood, C.K.: Chronic inhalation toxicity/carcinogenicity study in rats exposed to fluorocarbon 113 (FC-113). Fundam. Appl. Toxicol. 11(1): 68-75, 1988.
- Woollen, B.H., et al.: Human inhalation pharmacokinetics of 1,1,2-trichloro-1,2,2-trifluoroethane (FC113). Int. Arch. Occup. Environ. Health 62(1): 73-78, 1990.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
-
sampling media: Two Anasorb CMS Tubes in Series (150/75 mg sections)
analytical solvent: Carbon Disulfide
maximum volume: 1 Liter maximum flow rate: 0.05 L/min (TWA)
maximum volume: 0.75 Liters maximum flow rate: 0.05 L/min (STEL)
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA 113)
method classification: Fully Validated
* All Trademarks are the property of their respective owners.
|
|
|
|
 |
|
Back to Top
www.osha.gov
