Chemical Sampling Information
	1,2,4-Trichlorobenzene
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: unsym-Trichlorobenzene; 1,2,4-Trichlorobenzol OSHA IMIS Code Number: 2481 Chemical Abstracts Service (CAS) Registry Number: 120-82-1 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: DC2100000 Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2321 153 (liquid) [27 KB, PDF] NIOSH Pocket Guide to Chemical Hazards, 1,2,4-Trichlorobenzene: chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 37 mg/m3 Ceiling National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 40 mg/m3 Ceiling Health Factors Environmental Protection Agency (EPA) carcinogenic classification: Group D, not classifiable as to human carcinogenicity Potential symptoms: Irritation of eyes, skin, mucous membrane; in animals: liver, kidney damage; possible teratogenic effects; INGES. ACUTE: Abdominal pain, vomiting. Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); Liver damage (HE4). Affected organs: Eyes, skin, respiratory system, liver, reproductive system Notes: OSHA does not have a PEL for 1,2,4-trichlorobenzene. EPA’s oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) of 1,2,4-trichlorobenzene is 0.01 mg/kg/day. Rat liver microsomes metabolize 1,2,4-trichlorobenzene predominantly to 2,3,6-trichlorophenol and 2,4,5-trichlorophenol. Relatively small amounts of other trichlorophenol isomers are also produced. Covalent binding to microsomal protein during this metabolism is thought to be due to the formation of reactive quinone metabolites. Date Last Revised: 04/02/2007 Literature Basis: NIOSH Pocket Guide to Chemical Hazards: 1,2,4-Trichlorobenzene. International Chemical Safety Cards (WHO/IPCS/ILO): 1,2,4-Trichlorobenzene. U.S. EPA Integrated Risk Information System: 1,2,4-Trichlorobenzene (CASRN 120-82-1). den Besten, C., Smink, M.C., de Vries, E.J. and van Bladeren, P.J.: Metabolic activation of 1,2,4-trichlorobenzene and pentachlorobenzene by rat liver microsomes: a major role for quinone metabolites. Toxicol. Appl. Pharmacol. 108(2): 223-233, 1991. den Besten, C., et al.: The liver, kidney, and thyroid toxicity of chlorinated benzenes. Toxicol. Appl. Pharmacol. 111(1): 69-81, 1991. Pohanish, R.P. (editor): 1,2,4-Trichlorobenzene. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2242-2244. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Teflon Filter (Type LS) followed by an Amberlite XAD-2 Tube (100/50 mg sections, 20/50 mesh) analytical solvent: Hexane minimum time: 15 Minutes   maximum time: 60 Minutes   maximum flow rate: 0.2 L/min (Ceiling) current analytical method: Gas Chromatography; GC/ECD method reference: NIOSH Analytical Method (NIOSH 5517) [24 KB, PDF] method classification: Fully Validated All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.