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Chemical Sampling Information (CSI)
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General Description

Synonyms: ortho-Aminotoluene; o-Methylaniline; 1-Methyl-1,2-amino-benzene; 2-Methylaniline

OSHA IMIS Code Number: 2475

Chemical Abstracts Service (CAS) Registry Number: 95-53-4

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: XU2975000; 83249

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: UN 1708 Poison 153

NIOSH Pocket Guide to Chemical Hazards, o-Toluidine: Chemical description, physical properties, potentially hazardous incompatibilities, and more

Chemical Description and Physical Properties:
colorless to pale yellow liquid with a weak, aromatic odor
molecular weight: 107
boiling point: 391°F
vapor pressure: <1 mm
melting point: -3°F
Incompatibilities: Strong oxidizers
Exposure Limits

OSHA Permissible Exposure Limit (PEL):
General Industry: 5 ppm, 22 mg/m3 (Skin)

Construction Industry: 5 ppm, 22 mg/m3 TWA (Skin)
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 2 ppm, 8.8 mg/m3 TWA (Skin); Appendix A3 (Confirmed Animal Carcinogen with Unknown Relevance to Humans)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Potential Carcinogen; lowest feasible concentration (Skin)

Health Factors

Carcinogenic Classification:
International Agency for Research on Cancer (IARC): Group 2B, possibly carcinogenic to humans (3,3'-Dimethylbenzidine) [479 KB PDF, 63 pages]

National Toxicology Program (NTP): Reasonably anticipated to be a human carcinogen [121 KB PDF, 2 pages]
Potential Symptoms: Anoxia; headaches; cyanosis; weakness, dizziness, drowsiness, micro hematuria; eye burns; dermatitis; (carcinogenic)

Health Effects: Methemoglobinemia (HE13); Acute systemic effects (HE4)

Affected Organs: Blood, kidneys, liver, CVS, skin, eyes
Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • sampling media: Coated Glass Fiber Filters (37 mm) in 3 piece cassette. Coating is Sulfuric Acid.
    maximum volume: 100 Liters   
    maximum flow rate:     1.0 L/min
    current analytical method: Gas Chromatography; GC/ECD
    method reference: 2 (OSHA 73)
    sampling and analytical error: 0.09
    method classification: Fully Validated
    note: Filters may be obtained by OSHA personnel from SLTC.
Secondary Sampling/Analytical Method (SAM2):
  • device: Detector Tube
    company:     Gastec
    part #: 181
    range:     2.5-35 ppm
    classification: Mfg
  • device: Instrumentation
    company:     Infrared Spectrophotometer
    part #: MIRAN 1A & 1B
    range:     0.9 ppm @ 13.5 um
    classification: Mfg
Bulk Method: Limit the amount of bulk submitted to one gram or one mL.

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Page last updated: 01/19/1999

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