Chemical Sampling Information
	Toluene-2,4-diisocyanate (TDI)
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: 2,4-Diisocyanato-1-methylbenzene; TDI; 2,4-TDI; 2,4-Toluene diisocyanate OSHA IMIS Code Number: 2470 IMIS Name History: Toluene-2,4-Diisocyanate prior to 9/1/89 Chemical Abstracts Service (CAS) Registry Number: 584-84-9 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: CZ6300000 Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2078 156 [27 KB, PDF] NIOSH Pocket Guide to Chemical Hazards, Toluene-2,4-Diisocyanate: chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 0.02 ppm, 0.14 mg/m3 Ceiling OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 0.02 ppm, 0.14 mg/m3 Ceiling OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 0.02 ppm, 0.14 mg/m3 Ceiling American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.005 ppm, 0.036 mg/m3 TWA; 0.02 ppm, 0.14 mg/m3 STEL; SEN; Appendix A4 - Not Classifiable as a Human Carcinogen National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Appendix A - NIOSH Potential Occupational Carcinogens Health Factors NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 2.5 ppm Potential symptoms: Nose, throat irritation; choking, paroxysmal coughing; chest pain; retrosternal soreness; nausea, vomiting, abdominal pain; bronchial spasms; pulmonary edema; wheezing, dyspnea, asthma; conjunctivitis, lacrimation, blurred vision; dermatitis, skin sensitization, pain; (carcinogenic) Health Effects: Respiratory sensitization---Asthma (HE9); Dermatitis (HE3); Irritation-Eye, Nose, Throat, Skin---Marked (HE14) Affected organs: Respiratory system, skin, eyes Note: Death from severe asthma in sensitized workers has been reported. Date Last Revised: 07/21/2003 Literature Basis: Ott, M.G., Diller, W.F. and Jolly, A.T.: Respiratory effects of toluene diisocyanate in the workplace: A discussion of exposure-response relationships. Critical Rev. Toxicol. 33(1): 1-59, 2003. International Chemical Safety Cards (WHO/IPCS/ILO): 2,4-Toluene diisocyanate. NIOSH Alert - 1996: Preventing asthma and death from diisocyanate exposure. DHHS (NIOSH) Publication No. 96-111. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Coated Glass Fiber Filter (37 mm open face) Coated with 1.0 mg 1-(2-Pyridyl)piperazine analytical solvent: 90/10 (v/v) Acetonitrile/Dimethyl Sulfoxide maximum volume: 240 Liters   maximum flow rate: 1.0 L/min (TWA) maximum volume: 15 Liters   maximum flow rate: 1.0 L/min (STEL) maximum volume: 15 Liters   maximum flow rate: 1.0 L/min (Ceiling) current analytical method: High Performance Liquid Chromatography; HPLC/UV/FLU method reference: OSHA Manual of Analytical Methods (OSHA 42) method classification: Fully Validated note: OSHA personnel may obtain filters from SLTC and refrigerate until used. On-Site Sampling Techniques/Method: device: Detector Tube manufacturer: Dräger model/type: Toluene Diisocyanate 0.02/a, order no. 67 24501 sampling information: 25 strokes upper measurement limit: 0.2 ppm detection limit: approx. 0.02 ppm standard deviation: ±30% method reference: on-site air secondary (manufacturer) All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.