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Chemical Sampling Information (CSI)
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General Description

Synonyms: 2-Methylaziridine

OSHA IMIS Code Number: 2213

Chemical Abstracts Service (CAS) Registry Number: 75-55-8

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: CM8050000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: UN1921 Flammable Liquid, Poison

Chemical Description and Physical Properties:

fuming, colorless liquid with a strong ammonia-like odor
molecular weight: 57
boiling point: 151°F

Incompatibilities: Acids, strong oxidizers

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 2 ppm, 5 mg/m3 (Skin)

Construction Industry: 2 ppm, 5 mg/m3 (Skin)

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 2 ppm, 4.7 mg/m3 (Skin); Appendix A3 (Confirmed Animal Carcinogen with Unknown Relevance to Humans)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Potential Carcinogen, 2 ppm TWA (Skin)

Health Factors

Carcinogenic Classification:

International Agency for Research on Cancer (IARC): Group 2B, possibly carcinogenic to humans (2-Methylaziridine)

Potential Symptoms: Eye, skin burns; (carcinogenic)

Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15) CNS depression (HE7); Cumulative liver damage (HE3) Mutagen (HE2)

Affected Organs: Eyes, skin

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Midget Fritted Glass Bubbler (MFGB) containing 15 mL Folins Reagent
    maximum volume: 48 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: 2 (OSHA In-House File)
    method classification: Not Validated
    note: OSHA personnel should obtain Folins reagent from the Salt Lake Technical Center. Store reagent in a refrigerator and discard after 5 days. While sampling, wrap impingers and vials with aluminum foil to protect from light. After sampling keep samples cool. Ship samples to the Salt Lake Technical Center by overnight carrier packaged in a container with cold packs. Notify C/P Branch chief, Salt Lake Technical Center, that samples are being shipped.

Conditions: Chloroform extraction; C18 column; 50% methanol 50% water; 1.3 mL/min; UV Det: 254; Retention time, 5 min; C/P KM NOTE: Follin's Reagent should be obtained from scale. Wrap and vials with aluminum foil to protect from light. Store in a refrigerator. Discard reagent after 5 days.

Secondary Laboratory Sampling/Analytical Method (SAM2):

  • part #: 92115
    range: 2-300 ppm

  • part #: CH 31801
    range: 0.25-3.0 ppm

  • part #: 180
    range: 1-60 ppm

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