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2-Propoxyethanol

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General Description
    Synonyms: EGPE; Ethylene glycol monopropyl ether; Propyl Cellosolve; Propylglycol

    OSHA IMIS Code Number: P136

    Chemical Abstracts Service (CAS) Registry Number: 2807-30-9

    NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KM2800000

    Chemical Description and Physical Properties: Clear colorless flammable liquid; soluble in water and most solvents. Mild reasonably pleasant odor.
      molecular formula: C5H12O2
      molecular weight: 104.149
      boiling point: 149.5-150.5°C
      vapor pressure: 130 Pa @ 25°C
      melting point: -90°C
Health Factors
    Potential symptoms: Eye, nose, throat and skin irritation; cough, sore throat; eye redness, pain; dry skin.

    Health Effects: Irritation-Eyes---Marked (HE14); Irritation-Nose, Throat, Skin---Mild (HE16); Blood disorders (HE12)

    Affected organs: Eyes, skin, respiratory system, blood

    Notes:
    1. Explosive vapor/air mixtures may be formed with 2-propoxyethanol at temperatures above 57°C.
    2. No reports of adverse effects on humans were found in the literature. Oral and inhalational studies in rats indicated red blood cells as the primary site of action (hematuria), with secondary changes occurring in spleen, liver and kidneys. The overall NOEL of 2-propoxyethanol in inhalational studies was reported to be 200 ppm.

    Date Last Revised: 09/20/2006

    Literature Basis:
    • International Chemical Safety Cards (WHO/IPCS/ILO): Ethylene glycol monopropyl ether.
    • Katz, G.V., Krasavage, W.J. and Terhaar, C.J.: Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate. Environ. Health Perspect. 57: 165-175, 1984
Monitoring Methods used by OSHA
    Laboratory Sampling/Analytical Method:

    • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
      analytical solvent: (95:5) Methylene Chloride:Methanol
      maximum volume: 10 Liters   maximum flow rate: 0.2 L/min
      current analytical method: Gas Chromatography; GC/FID
      method reference: OSHA SLTC In-House File
      method classification: Not Validated

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