Chemical Sampling Information
2-Propoxyethanol
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General Description
Synonyms: EGPE; Ethylene glycol monopropyl ether; Propyl Cellosolve; Propylglycol
OSHA IMIS Code Number: P136
Chemical Abstracts Service (CAS) Registry Number: 2807-30-9
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KM2800000
Chemical Description and Physical Properties: Clear colorless flammable liquid; soluble in water and most solvents. Mild reasonably pleasant odor.
molecular formula: C5 H12 O2
molecular weight: 104.149
boiling point: 149.5-150.5°C
vapor pressure: 130 Pa @ 25°C
melting point: -90°C
Health Factors
Potential symptoms: Eye, nose, throat and skin irritation; cough, sore throat; eye redness, pain; dry skin.
Health Effects: Irritation-Eyes---Marked (HE14); Irritation-Nose, Throat, Skin---Mild (HE16); Blood disorders (HE12)
Affected organs: Eyes, skin, respiratory system, blood
Notes:
Explosive vapor/air mixtures may be formed with 2-propoxyethanol at temperatures above 57°C.
No reports of adverse effects on humans were found in the literature. Oral and inhalational studies in rats indicated red blood cells as the primary site of action (hematuria), with secondary changes occurring in spleen, liver and kidneys. The overall NOEL of 2-propoxyethanol in inhalational studies was reported to be 200 ppm.
Date Last Revised: 09/20/2006
Literature Basis:
International Chemical Safety Cards (WHO/IPCS/ILO): Ethylene glycol monopropyl ether .
Katz, G.V., Krasavage, W.J. and Terhaar, C.J.: Comparative acute and subchronic toxicity of ethylene glycol monopropyl ether and ethylene glycol monopropyl ether acetate. Environ. Health Perspect. 57 : 165-175, 1984
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: (95:5) Methylene Chloride:Methanol
maximum volume: 10 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA SLTC In-House File
method classification: Not Validated
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