Synonyms: o-(2-(Diethylamino)-6-Methyl-4-Pyrimidinyl) o,o-Dimethyl Ester Phosphorothioic Acid; Pyridimine Phosphate; Plant Protection; PP511; Actellifog; Blex; Silosan

OSHA IMIS Code Number: P309

Chemical Abstracts Service (CAS) Registry Number: 29232-93-7

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: TF1410000

Chemical Description and Physical Properties:

molecular formula: C₁₁H₂₀N₃O₃PS
molecular weight: 305.37
vapor pressure: 0.015 Pa (1.1×10^-4 mmHg) at 30°C

Potential Symptoms: Headache, nausea, vomiting, abdominal cramps, diarrhea; dizziness, sweating; extreme weakness, ataxia; miosis, blurred vision; twitching, tremor; slow heart beat; difficulty breathing, tightness in chest, pulmonary edema.

Health Effects: Cholinesterase inhibition (HE6); Chronic toxicity (kidney, liver) (HE3); LD50 (dermal, rabbit) 2128 mg/kg.

Affected Organs: Respiratory system, CNS, cardiovascular system, skeletal muscle (motor endplate)

Notes:

1. Used primarily for grain (corn, wheat) storage. One report indicated sprayer exposure to be predominantly dermal.
2. A common biomarker of exposure is the measurement of acetylcholinesterase activity in red blood cells.
3. Several liver protease enzymes were inhibited by a single 10 mg/kg dose in rats.
4. No chronic inhalation toxicity studies were found in the literature. OSHA does not have a PEL for pirimiphos-methyl.

Date Last Revised: 04/28/2004

Literature Basis:

• Adamis, Z. Antal, A., Füzesi, I., Molnár, J., Nagy, L. and Susán, M.: Occupational exposure to organophosphorus insecticides and synthetic pyrethroid. Int. Arch. Occup. Environ. Health 56(4): 299-305, 1985.
• Agrisolutions: Material safety data sheet: Actellic® 5E Insecticide. 1999.
• Diwan, S.: Pirimiphos-methyl: toxicology chapter of the registration eligibility document. U.S. Environmental Protection Agency, Toxicology Branch (HED DOC No. 012554) 1998, 22 pp.
• Mantle, D., Saleem, M.A., Williams, F.M., Wilkins, R.M. and Shakoori, A.R.: Effect of pirimiphos-methyl on proteolytic enzyme activities in rat heart, kidney, brain and liver tissues in vivo. Clin. Chim. Acta 262(1-2): 89-97, 1997.

Laboratory Sampling/Analytical Method:

• sampling media: OSHA Versatile Sampler (OVS-2) - (each OVS-2 sampler contains a glass fiber filter and two sections (270/140 mg, 20/60 mesh) of XAD-2 adsorbent)
  analytical solvent: Acetonitrile
  maximum volume: 120 Liters
  maximum flow rate: 1.0 L/min
  current analytical method: Gas Chromatography; GC/ECD
  method reference: OSHA Analytical Method (OSHA PV2071)
  method classification: Partially Validated
  

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