Chemical Sampling Information
	N-Nitrosopiperidine
Quick Links General Description Health Factors Monitoring Search    [use word(s)/phrase ] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: NPIP; NO-Pip; 1-Nitrosopiperidine OSHA IMIS Code Number: 1949 Chemical Abstracts Service (CAS) Registry Number: 100-75-4 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: TN2100000 Chemical Description and Physical Properties: yellow liquid molecular formula: C5H10N2O molecular weight: 114.15 boiling point: 217°C/721 mm Hg Health Factors National Toxicology Program (NTP) carcinogenic classification: Reasonably Anticipated to be Human Carcinogen [217 KB PDF] International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, possibly carcinogenic to humans Potential symptoms: Irritation of eyes, inflammation of pigmented area, clouded patches of vision from corneal damage; liver damage. Health Effects: Suspected carcinogen (HE2); Possible permanent damage to eyes (HE14) Affected organs: Eyes; in rats: esophagus, liver, nasal cavity, stomach Notes: N-Nitrosopiperidine is an OSHA Select Carcinogen without a PEL, and it appears to be used only as a research chemical. It is thought to undergo activation by α-hydroxylation via the cytochrome P450 2A family (e.g., CYP2A6) to metabolites that form adducts with guanine in DNA, which may be involved in carcinogenesis. N-Nitrosopiperidine has been found in some sun-dried foods, smoked fish, meats (e.g., bacon) and other foods preserved with sodium nitrite. N-Nitrosopiperidine was detected in urine from 52/59 non-smokers who were tested, and it appeared to be associated with the consumption of coffee, according to one report. Date Last Revised: 08/16/2006 Literature Basis: No Author: N-Nitrosopiperidine, CAS No. 100-75-4. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 2005. [217 KB PDF] Levallois, P., et al.: Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption. Food Chem. Toxicol. 38(11): 1013-1019, 2000. Pohanish, R.P. (editor): N-Nitrosopiperidine. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1741-1742. Siddiqi, M.A., Tricker, A.R., Kumar, R., Fazili, Z. and Preussmann, R.: Dietary sources of N-nitrosamines in a high-risk area for oesophageal cancer—Kashmir, India. IARC Sci. Publ. (105): 210-213, 1991. Wong, H.L., Murphy, S.E. and Hecht, S.S.: Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N’-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. Chem. Res. Toxicol. 18(1): 61-69, 2005. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: ThermoSorb/N Tube analytical solvent: (75:25) Dichloromethane:Methanol maximum volume: 75 Liters   maximum flow rate: 1.0 L/min current analytical method: Gas Chromatography; GC/TEA method reference: OSHA Analytical Method (OSHA 27) method classification: Fully Validated note: OSHA personnel may obtain ThermoSorb/N Tube from SLTC. Store samples in freezer. Bulk method: Limit the amount of bulk submitted to one gram or one mL. All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.